Hilton G
Department of Adult Health Nursing, School of Nursing, University of Maryland, Baltimore 21201, USA.
J Neurosci Nurs. 2000 Oct;32(5):278-82. doi: 10.1097/01376517-200010000-00008.
Secondary brain injury results in increased morbidity and mortality in the traumatically brain-injured (TBI) patient. Research has shown that prevention of secondary brain injury, as characterized by cerebral ischemia and edema, can improve neurologic outcomes. The standard of care in many facilities is to monitor intracranial pressure and cerebral perfusion pressure as indirect measures of cerebral oxygenation and perfusion and to therefore manage secondary brain injury via these parameters. Yet these may not be the most accurate or reliable measures of cerebral oxygenation. Scientifically, brain tissue oxygenation can be directly measured via the partial pressure of oxygen in brain tissue (PbO2) probe. This provides a rapid, potentially more accurate indicator of cerebral oxygenation, thereby allowing for earlier intervention into the prevention of secondary brain injury.
继发性脑损伤会导致创伤性脑损伤（TBI）患者的发病率和死亡率增加。研究表明，预防以脑缺血和水肿为特征的继发性脑损伤可以改善神经功能预后。许多医疗机构的护理标准是监测颅内压和脑灌注压，作为脑氧合和灌注的间接指标，从而通过这些参数来管理继发性脑损伤。然而，这些可能并不是脑氧合最准确或可靠的指标。从科学角度来看，脑组织氧合可以通过脑组织氧分压（PbO2）探头直接测量。这提供了一个快速、可能更准确的脑氧合指标，从而能够更早地干预继发性脑损伤的预防。
