Apte M G, Fisk W J, Daisey J M
Indoor Environment Department, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Indoor Air. 2000 Dec;10(4):246-57. doi: 10.1034/j.1600-0668.2000.010004246.x.
Higher indoor concentrations of air pollutants due, in part, to lower ventilation rates are a potential cause of sick building syndrome (SBS) symptoms in office workers. The indoor carbon dioxide (CO2) concentration is an approximate surrogate for indoor concentrations of other occupant-generated pollutants and for ventilation rate per occupant. Using multivariate logistic regression (MLR) analyses, we evaluated the relationship between indoor CO2 concentrations and SBS symptoms in occupants from a probability sample of 41 U.S. office buildings. Two CO2 metrics were constructed: average workday indoor minus average outdoor CO2 (dCO2, range 6-418 ppm), and maximum indoor 1-h moving average CO2 minus outdoor CO2 concentrations (dCO2MAX). MLR analyses quantified dCO2/SBS symptom associations, adjusting for personal and environmental factors. A dose-response relationship (p < 0.05) with odds ratios per 100 ppm dCO2 ranging from 1.2 to 1.5 for sore throat, nose/sinus, tight chest, and wheezing was observed. The dCO2MAX/SBS regression results were similar.
部分由于通风率较低导致的室内空气污染物浓度升高，是办公室工作人员出现病态建筑综合征（SBS）症状的一个潜在原因。室内二氧化碳（CO2）浓度大致可替代其他由居住者产生的污染物的室内浓度以及每位居住者的通风率。我们使用多变量逻辑回归（MLR）分析，从美国41座办公楼的概率样本中评估了居住者室内CO2浓度与SBS症状之间的关系。构建了两个CO2指标：工作日室内平均CO2浓度减去室外平均CO2浓度（dCO2，范围为6 - 418 ppm），以及室内1小时移动平均CO2浓度最大值减去室外CO2浓度（dCO2MAX）。MLR分析对dCO2与SBS症状之间的关联进行了量化，并对个人和环境因素进行了调整。观察到存在剂量反应关系（p < 0.05），每100 ppm dCO2导致喉咙痛、鼻子/鼻窦、胸闷和喘息的优势比在1.2至1.5之间。dCO2MAX与SBS的回归结果相似。
