妊娠与艾滋病进展：法国前瞻性队列研究结果。SEROGEST和SEROCO研究组
Pregnancy and progression to AIDS: results of the French prospective cohorts. SEROGEST and SEROCO Study Groups.
作者信息
Saada M, Le Chenadec J, Berrebi A, Bongain A, Delfraissy J F, Mayaux M J, Meyer L
机构信息
Service d'Epidémiologie and INSERM U292, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France.
出版信息
AIDS. 2000 Oct 20;14(15):2355-60. doi: 10.1097/00002030-200010200-00017.
OBJECTIVE
To investigate whether pregnancy accelerates HIV-1 disease progression.
METHOD
In two large French SEROCO and SEROGEST prospective cohorts of HIV infected patients, the progression to AIDS in 365 women with a known date of HIV-1 seroconversion was examined by comparing those who delivered after HIV infection (n = 241) with those who did not become pregnant while HIV-infected (n = 124).
RESULTS
The crude relative risk of developing AIDS associated with pregnancy was 0.7 [95% confidence interval (CI), 0.4-1.2]. Adjustment for age at seroconversion, the CD4+ cell percentage at entry, and the method used to date seroconversion did not modify the results (adjusted relative risk, 0.7; 95% CI 0.4-1.2).
CONCLUSIONS
No deleterious effect of pregnancy on progression from seroconversion to AIDS was found. This result has important implications for the counselling of HIV-infected women of child-bearing age.
目的
研究妊娠是否会加速HIV-1疾病进展。
方法
在法国两个大型的SEROCO和SEROGEST前瞻性HIV感染患者队列中，通过比较HIV感染后分娩的女性（n = 241）和HIV感染期间未怀孕的女性（n = 124），研究了365名已知HIV-1血清转化日期的女性进展为艾滋病的情况。
结果
与妊娠相关的发生艾滋病的粗相对风险为0.7 [95%置信区间（CI），0.4 - 1.2]。对血清转化时的年龄、入组时CD4 +细胞百分比以及确定血清转化日期所用方法进行校正后，结果未改变（校正相对风险，0.7；95% CI 0.4 - 1.2）。
结论
未发现妊娠对从血清转化到艾滋病进展有有害影响。该结果对育龄期HIV感染女性的咨询具有重要意义。
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