Lawn N D, Westmoreland B F, Sharbrough F W
Department of Neurology, Mayo Clinic and Mayo Foundation, 200 First Street SW, MN 55905, Rochester, USA.
Clin Neurophysiol. 2000 Dec;111(12):2125-9. doi: 10.1016/s1388-2457(00)00466-1.
To analyze the clinical and EEG findings of patients with multifocal periodic lateralized epileptiform discharges (PLEDs).
EEGs containing multifocal PLEDs (3 or more foci of PLEDs) were reviewed. Thirty-five patients (15 males and 20 females), from 2.5 months to 91 years old, met the criteria for multifocal PLEDs.
The disease processes identified in the patients included vascular lesions in 9, central nervous system infections in 7, metabolic/toxic disorders in 6, exacerbation of a chronic seizure disorder in 6, hypoxic ischemic insults in 3, and fat embolism, paraneoplastic encephalitis, cerebral metastasis, and multiple sclerosis in one each. Twenty patients died. Detection of the spatiotemporal distribution of multifocal PLEDs was facilitated by the use of Laplacian montages.
Multifocal PLEDs were recorded in 35 patients and were associated with processes resulting in diffuse or multifocal cerebral dysfunction. Multifocal PLEDs indicate a significant disturbance of cerebral function and are associated with a mortality rate of 57%.
分析多灶性周期性一侧性癫痫样放电（PLEDs）患者的临床和脑电图表现。
回顾包含多灶性PLEDs（3个或更多PLEDs病灶）的脑电图。35例患者（15例男性和20例女性），年龄从2.5个月至91岁，符合多灶性PLEDs标准。
患者中确定的疾病过程包括9例血管病变、7例中枢神经系统感染、6例代谢/中毒性疾病、6例慢性癫痫疾病加重、3例缺氧缺血性损伤，以及各1例脂肪栓塞、副肿瘤性脑炎、脑转移和多发性硬化。20例患者死亡。使用拉普拉斯导联有助于检测多灶性PLEDs的时空分布。
35例患者记录到多灶性PLEDs，其与导致弥漫性或多灶性脑功能障碍的过程相关。多灶性PLEDs表明脑功能存在显著紊乱，且死亡率为57%。
