Snodgrass S M, Tsuburaya K, Ajmone-Marsan C
Department of Neurology, EEG Laboratory, University of Miami School of Medicine, Florida 33101.
J Clin Neurophysiol. 1989 Apr;6(2):159-72. doi: 10.1097/00004691-198904000-00003.
A retrospective study was carried out in 147 patients who had been found to have periodic lateralized epileptiform discharges (PLEDs). Clinical, laboratory, radiological, and pathological correlation was performed for all patients. As in previously published works, we found a high correlation with cerebrovascular accidents in our population. A large number of patients, however, had no evidence of focal central nervous system pathology. An attempt was made to find a temporal relationship between the onset of seizure activity (or neurological dysfunction in those patients without seizure activity) and the recording of an EEG with PLEDs. We found that most of the EEGs with PLEDs were obtained within the first 4 days of seizure activity or status epilepticus condition. We postulate that the EEG phenomenon of PLEDs could be considered a part of the status epilepticus condition. Suggestive of this was the fact that the first EEG record obtained in one-third of our patients showed electrographic partial status epilepticus. In a small percentage of our patients, a transitional record showed first status epilepticus and then PLEDs. We found that PLEDs usually disappeared from the EEG tracing within 9 days post-ictus flash status. They were most frequently replaced by focal slowing or random spike activity.
对147例被发现有周期性一侧性癫痫样放电（PLEDs）的患者进行了一项回顾性研究。对所有患者进行了临床、实验室、放射学和病理学相关性分析。与之前发表的研究一样，我们发现在我们的研究人群中，PLEDs与脑血管意外有高度相关性。然而，大量患者没有中枢神经系统局灶性病变的证据。我们试图找出癫痫发作活动（或无癫痫发作活动患者的神经功能障碍）的发作与记录到PLEDs的脑电图之间的时间关系。我们发现，大多数有PLEDs的脑电图是在癫痫发作活动或癫痫持续状态的前4天内获得的。我们推测，PLEDs的脑电图现象可被视为癫痫持续状态的一部分。我们三分之一的患者首次脑电图记录显示为脑电图部分性癫痫持续状态，这一事实提示了这一点。在我们一小部分患者中，一份过渡性记录显示先是癫痫持续状态，然后是PLEDs。我们发现，PLEDs通常在发作后闪光状态9天内从脑电图描记中消失。它们最常被局灶性慢波或随机棘波活动所取代。
