同时检测囊液中的ErbB-2蛋白和癌胚抗原以辅助诊断乳腺囊性病变

Simultaneous Assay of ErbB-2 Protein and Carcinoembryonic Antigen in Cyst Fluid as an Aid in Diagnosing Cystic Lesions of the Breast.

作者信息

Inaji H, Koyama H, Motomura K, Noguchi S, Tsuji N, Kimura Y, Sato H, Sugano K, Ohkura H

机构信息

Departements of Surgery, The Center for Adult Diseases, Osaka, 3 Nakamichi 1-Chome, Higashinari-ku, Osaka 537, Japan.

出版信息

Breast Cancer. 1994 Jul 30;1(1):25-30. doi: 10.1007/BF02967371.

DOI:10.1007/BF02967371

PMID:11091503

Abstract

C-erbB-2 oncoprotein (ErbB-2 protein)and carcinoembryonic antigen (CEA)were simultaneously evaluated in the breast cyst fluid of 6 patients with intracystic cancer, 6 patients with intracystic papilloma, and 42 patients with gross cystic disease. A combination test, using 12 ng of ErbB-2 protein and 150 ng of CEA/ml of cyst fluid, respectively, as cutoff values resulted in a positive detection rate of 83%(5/6 cases) for intracystic breast cancer. Two of the 6 patients with intracystic papilloma and 2 of the 42 patients with gross cystic disease were positive. In addition, elevated levels of these markers in cyst fluid correlated well with the expression of these antigens in the corresponding tumor. Thus, it can be concluded that measurements of ErbB-2 protein and CEA aid in the diagnosis of intracystic breast cancer, and the assay of ErbB-2 protein is valuable for detecting tumors in which this protein is overexpressed.

摘要

对6例囊内癌患者、6例囊内乳头状瘤患者及42例乳腺大囊性病患者的乳腺囊肿液同时进行C - erbB - 2癌蛋白（ErbB - 2蛋白）和癌胚抗原（CEA）检测。分别以12 ng ErbB - 2蛋白和150 ng CEA/毫升囊肿液作为临界值进行联合检测，囊内乳腺癌的阳性检出率为83%（5/6例）。6例囊内乳头状瘤患者中有2例、42例乳腺大囊性病患者中有2例检测结果呈阳性。此外，囊肿液中这些标志物水平的升高与相应肿瘤中这些抗原的表达密切相关。因此，可以得出结论，检测ErbB - 2蛋白和CEA有助于囊内乳腺癌的诊断，检测ErbB - 2蛋白对检测该蛋白过表达的肿瘤具有重要价值。