爱泼斯坦-巴尔病毒感染在鼻咽癌发病机制中的作用
Epstein-Barr virus infection in the pathogenesis of nasopharyngeal carcinoma.
作者信息
Niedobitek G
机构信息
Institute for Pathology, Friedrich-Alexander-University, Erlangen, Germany.
出版信息
Mol Pathol. 2000 Oct;53(5):248-54. doi: 10.1136/mp.53.5.248.
Abstract
The association of nasopharyngeal carcinoma (NPC) with the Epstein-Barr virus (EBV) was firmly established as early as 1973. Nevertheless, the role for the virus in the pathogenesis of NPC is still controversial. In this article, the evidence implicating EBV in the development of NPC is reviewed, focusing on the cellular site of EBV persistence, the association of the virus with different NPC histotypes, the tumour cell phenotype in the context of viral latent gene expression, and the possible role of the lymphoid stroma.
摘要
早在1973年，鼻咽癌（NPC）与爱泼斯坦-巴尔病毒（EBV）之间的关联就已被确凿证实。然而，该病毒在鼻咽癌发病机制中的作用仍存在争议。在本文中，我们回顾了支持EBV与鼻咽癌发生相关的证据，重点关注EBV持续存在的细胞位点、该病毒与不同鼻咽癌组织学类型的关联、病毒潜伏基因表达背景下的肿瘤细胞表型，以及淋巴样基质的可能作用。
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