Zheng X, Yan L, Nilsson B, Eklund G, Drettner B
Department of Otolaryngology, Huddinge University Hospital, Karolinska Institute, Sweden.
Acta Oncol. 1994;33(8):867-72. doi: 10.3109/02841869409098448.
Two hundred and five histologically confirmed cases of nasopharyngeal carcinoma (NPC) in southern China, and an equal number of matched controls, were investigated for their dietary habits, occupational exposure, use of tobacco and alcohol, history of relatives with NPC, and IgA against Epstein-Barr virus (EBV) capsid antigen (IgA/VCA). Positive IgA/VCA and intake of salted fish were associated with a strong excess risk of NPC. The association persisted after adjustment for other factors. The combination of salted fish and EBV was strongly associated with NPC, and more so than EBV or salted fish per se. Multivariate analyses showed that IgA/VCA was the most important predictor of NPC, and salted fish the second most important. These results suggest that EBV has a strong effect on the development of NPC. The exclusion of EBV and genetic factors in earlier epidemiological studies may have resulted in an overestimation of salted fish as important etiological factor causing NPC.
对中国南方205例经组织学确诊的鼻咽癌（NPC）病例以及数量相等的匹配对照，就其饮食习惯、职业暴露、烟草和酒精使用情况、亲属患鼻咽癌的病史以及抗Epstein-Barr病毒（EBV）衣壳抗原的IgA（IgA/VCA）进行了调查。IgA/VCA呈阳性以及食用咸鱼与患鼻咽癌的风险大幅增加相关。在对其他因素进行调整后，这种关联依然存在。咸鱼与EBV共同作用与鼻咽癌的关联很强，比单独的EBV或咸鱼本身的关联更强。多变量分析表明，IgA/VCA是鼻咽癌最重要的预测因素，咸鱼是第二重要的因素。这些结果表明，EBV对鼻咽癌的发生有很强的影响。早期流行病学研究中排除EBV和遗传因素可能导致高估了咸鱼作为导致鼻咽癌的重要病因因素的作用。
