Niedobitek G, Agathanggelou A, Nicholls J M
Department of Pathology, University of Birmingham, UK.
Semin Cancer Biol. 1996 Aug;7(4):165-74. doi: 10.1006/scbi.1996.0023.
Nasopharyngeal carcinoma (NPC) is the human tumour showing the most consistent association with Epstein-Barr virus (EBV). The recent detection of EBV in in-situ NPC lesions has shed light on the sequence of events leading to the development of invasive NPC, and will be discussed in the context of what is known about EBV infection in non-neoplastic epithelial cells. The association of EBV with different histotypes of NPC will also be considered. EBV gene expression and NPC tumour cell phenotype will be discussed, and evidence will be presented suggesting that the lymphoid stroma characteristically found in undifferentiated NPC is a prerequisite for the development of this tumour.
鼻咽癌（NPC）是与爱泼斯坦-巴尔病毒（EBV）关联最为密切的人类肿瘤。近期在原位鼻咽癌病变中检测到EBV，这为侵袭性鼻咽癌发生发展过程中的一系列事件提供了线索，并将在非肿瘤性上皮细胞中EBV感染相关已知情况的背景下进行讨论。还将考虑EBV与不同组织学类型鼻咽癌的关联。将讨论EBV基因表达和鼻咽癌肿瘤细胞表型，并提供证据表明未分化鼻咽癌中典型存在的淋巴样基质是该肿瘤发生发展的一个先决条件。
