Jonsson H, Törnberg S, Nyström L, Lenner P
Department of Oncology, Umeå University, Sweden.
Acta Oncol. 2000;39(5):617-23. doi: 10.1080/028418600750013302.
The aim of the study was to develop a model for estimating the effect of the nation-wide service screening program with mammography on breast cancer mortality in Sweden. In 1997, the introduction of population-based service screening had been completed in all 26 counties. In approximately half of the counties suitable for evaluation, the lower age limit for invitation was 40 years (study population) and in the other half the age limit was 50 years (control population). The numbers of females aged 40 49 years for the two populations were 202,152 and 237,279, respectively (1988). The study and control populations were compared for the period 1986-1996 with regard to refined breast cancer mortality. To adjust for geographical differences, the period 1976 1986 was used as reference. With a mean follow-up time of 8 years, the estimated relative risk of breast cancer death in relation to invitation to service screening among women aged 40-49 years at breast cancer diagnosis was 0.91 (95% confidence interval 0.72-1.15). These findings were compatible with those presented in the previous overview of the Swedish randomized studies.
该研究的目的是建立一个模型，用于估计瑞典全国性乳腺钼靶筛查项目对乳腺癌死亡率的影响。1997年，基于人群的服务筛查在所有26个县全部完成。在大约一半适合评估的县，邀请筛查的年龄下限为40岁（研究人群），在另一半县年龄下限为50岁（对照人群）。这两个人群中40至49岁女性的数量分别为202,152人和237,279人（1988年）。对研究人群和对照人群在1986年至1996年期间的乳腺癌精算死亡率进行了比较。为了调整地理差异，将1976年至1986年期间作为参考。平均随访时间为8年，在乳腺癌诊断时年龄为40至49岁的女性中，与受邀参加服务筛查相关的乳腺癌死亡估计相对风险为0.91（95%置信区间0.72 - 1.15）。这些发现与瑞典随机研究的先前综述中呈现的结果一致。
