联体生活对受辐射应激大鼠寿命的影响。

The effect of parabiosis on life-span of rats stressed by radiation.

作者信息

Warren S, Chute R N, Porter M W

出版信息

J Gerontol. 1975 Jan;30(1):15-21. doi: 10.1093/geronj/30.1.15.

DOI:10.1093/geronj/30.1.15

Abstract

The life-spans of four series of NEDH rats were compared: (1) single control rats, (2) single rats irradiated with 1000 R, (3) control parabiont rats, (4) parabiont rats one of which had received 1000 R. The stress of radiation (1000 R) produced a median life shortening of 571 days in single rats. Parabiosis followed by irradiation (1000 R) of a member of the pair shortened life 132 days. Parabiosis alone produced a median life shortening of 62 days. Ninety percent of the older irradiated parabiont pairs died with one or more tumors present. Parabiosis largely protected animals from the gastrointestinal radiation syndrome.

摘要

比较了四组NEDH大鼠的寿命：（1）单只对照大鼠，（2）接受1000伦琴照射的单只大鼠，（3）联体对照大鼠，（4）其中一只接受了1000伦琴照射的联体大鼠。辐射应激（1000伦琴）使单只大鼠的中位寿命缩短了571天。联体后对其中一只进行照射（1000伦琴）使寿命缩短了132天。仅联体就使中位寿命缩短了62天。90%的老年受照射联体大鼠死于出现一个或多个肿瘤。联体在很大程度上保护动物免受胃肠道辐射综合征的影响。