Warren S, Brown C E
Arch Pathol Lab Med. 1978 May;102(5):224-6.
Parabiosis of paired NEDH rats and subsequent irradiation of one produced multiple stresses, particularly altered hormonal milieu. Benign mammary tumors developed in 8.6% of the control pairs, 12.7% of the shielded partners, and 19.7% of the irradiated rats. Mammary cancers developed in 5% of control pairs, 14.2% of the shielded partners, and 11.9% of the irradiated rats. With increased amounts of prolactin, the rate was 50% in shielded partner, 10% in the irradiated rats. Mesenchymal sarcoma develop at the anastomosis in parabiont rats. Their incidence rate in single controls is 3.1%, in parabiont control pairs 12.5%, in pairs with one partner irradiated 16.6%, and with both irradiated 23.1%. The incidence rate in other parts was increased threefold over controls in the irradiated partners. Radiation appears to be the dominant factor in both mammary and anastomotic tumors.
将成对的非动情期摘除卵巢大鼠进行联体生活，随后对其中一只进行照射，会产生多种应激，尤其是激素环境的改变。在对照组中，8.6%的大鼠出现良性乳腺肿瘤；在受保护的联体大鼠中，这一比例为12.7%；在接受照射的大鼠中，为19.7%。在对照组中，5%的大鼠发生乳腺癌；在受保护的联体大鼠中，为14.2%；在接受照射的大鼠中，为11.9%。催乳素水平升高时，受保护的联体大鼠患癌率为50%，接受照射的大鼠为10%。联体大鼠在吻合处发生间叶肉瘤。在单一对照组中，其发生率为3.1%；在联体对照组中，为12.5%；在一对联体大鼠中，若其中一只接受照射，发生率为16.6%；若两只都接受照射，发生率为23.1%。在接受照射的联体大鼠的其他部位，发生率比对照组增加了两倍。辐射似乎是乳腺肿瘤和吻合处肿瘤形成的主要因素。
