连续大剂量辐射对联体大鼠对的远期效应。

Late effects of successive massive doses of radiation on parabiont rat pairs.

作者信息

Warren S, Chute R N, Porter M W, Brown C E

出版信息

Int J Radiat Biol Relat Stud Phys Chem Med. 1978 Sep;34(3):265-71. doi: 10.1080/09553007814550851.

Abstract

Parabiosis of rats permits one partner to survive 1000 R X-radiation if the other is shielded. This dose to the previously shielded partner after intervals of 5, 10 or 30 days tests the ability of the first irradiated partner to recover and, in turn, support the second. The effectiveness of this can be measured by the late effects induced in the pair. Lifespan was shortened by 100--150 days following a 5-day interval, by 30 days following a 10-day interval and not shortened following a 30-day interval. The incidence of leukaemia was about 6 per cent in each group, close to that in control pairs. Shortening the interval between the irradiations decreased the average age of death from leukaemia. No solid lymphoid tumours were induced in the doubly irradiated pairs. The incidence of osteogenic sarcoma was 1.6 per cent in controls and 12.9 per cent in the pairs with both partners irradiated.

摘要

如果对其中一只大鼠进行屏蔽，另一只与之联体的大鼠可在接受1000伦琴的X射线辐射后存活下来。在5天、10天或30天的间隔后，对之前被屏蔽的这只大鼠给予相同剂量的辐射，以此测试第一只受辐射大鼠的恢复能力，以及它反过来支持第二只大鼠的能力。这一过程的有效性可通过联体大鼠所产生的晚期效应来衡量。间隔5天后，联体大鼠的寿命缩短了100 - 150天；间隔10天后，寿命缩短了30天；间隔30天后，寿命未缩短。每组白血病的发病率约为6%，与对照联体大鼠组相近。缩短两次辐射之间的间隔会降低白血病致死的平均年龄。在接受双重辐射的联体大鼠中未诱发实体淋巴肿瘤。对照组骨肉瘤的发病率为1.6%，两只大鼠均受辐射的联体大鼠组中骨肉瘤的发病率为12.9%。