Balomenos D, Martínez-A C
Dept. of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, UAM Campus de Cantoblanco, Madrid, Spain.
Immunol Today. 2000 Nov;21(11):551-5. doi: 10.1016/s0167-5699(00)01748-5.
To trigger an effective immune response, lymphocytes must proliferate. In addition to their direct involvement in cell-cycle progression, cell-cycle regulators might thus control immune functions. Recent evidence suggests that these regulators are essential for T-cell function; we argue that their study will provide clues for dissecting anergy and tolerance mechanisms, as well as for intervention in autoimmune diseases.
为引发有效的免疫反应，淋巴细胞必须增殖。因此，细胞周期调节因子除了直接参与细胞周期进程外，可能还控制着免疫功能。最近的证据表明，这些调节因子对T细胞功能至关重要；我们认为，对它们的研究将为剖析无反应性和耐受机制以及干预自身免疫性疾病提供线索。
