[联合暴露于掺入的137铯和外部γ射线照射下诱导小鼠产生显性致死突变的频率]

[Frequency of dominant lethal mutations induced by combined exposure to incorporated 137Cs and external gamma-irradiation in mice].

作者信息

Pomerantseva M D, Ramaia L K, Liaginskaia A M

机构信息

Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia.

出版信息

Genetika. 2000 Oct;36(10):1414-6.

PMID:11094757

Abstract

The genetic effect of combined exposure to incorporated 137Cs and external gamma-irradiation was studied in germ cells of male mice. The activity of incorporated 137Cs was 3.7 x 10(4) Bq/g. The dose of external gamma-irradiation was 1.5 Gy. In the case of combined exposure, mice were treated with a cesium solution immediately after irradiation. The genetic effect was estimated by the frequency of dominant lethal mutations (DLM) induced at different stages of spermatogenesis. Upon combined exposure to external and internal irradiation, the frequency of DLM in premeiotic cells significantly exceeded the total frequency of DLM induced by separate exposure to external and internal irradiation; i.e., a marked synergistic interaction of external and internal irradiation was observed.

摘要

研究了雄性小鼠生殖细胞中摄入的¹³⁷Cs与外照射γ射线联合暴露的遗传效应。摄入的¹³⁷Cs活度为3.7×10⁴Bq/g。外照射γ射线剂量为1.5 Gy。在联合暴露情况下，小鼠在照射后立即用铯溶液处理。通过在精子发生不同阶段诱导的显性致死突变（DLM）频率来评估遗传效应。在外照射与内照射联合暴露时，减数分裂前细胞中的DLM频率显著超过单独外照射和内照射诱导的DLM总频率；即观察到外照射与内照射有明显的协同相互作用。