Keay L, Harmis N, Corrigan K, Sweeney D, Willcox M
Cornea and Contact Lens Research Unit, School of Optometry and the Cooperative Research Centre for Eye Research and Technology, The University of New South Wales, Sydney, Australia.
Cornea. 2000 Nov;19(6):864-9. doi: 10.1097/00003226-200011000-00024.
Infiltrative keratitis is a common complication associated with extended wear of hydrogel lenses. Causative bacteria are often isolated from the lens at the time of an event. We report a case where three repeated occurrences of infiltrative keratitis were associated with contamination of the contact lenses by Abiotrophia defectiva.
A 34-year-old man participating in a clinical trial of extended wear hydrogel contact lenses experienced three episodes of infiltrative keratitis. The clinical presentation was observed using a biomicroscope. At the time of each event, the contact lenses were removed aseptically and ocular swabs were taken for bacterial identification and enumeration. The condition was monitored until full resolution.
The condition was characterized by irritation, marked bulbar and limbal injection, and multiple focal subepithelial infiltrates. Many of the infiltrates also showed overlying staining with fluorescein. In each of the three events of infiltrative keratitis, A. defectiva was cultured from the contact lens and ocular swabs.
This is the first reported occurrence of infiltrative keratitis associated with A. defectiva contamination of contact lenses.
浸润性角膜炎是水凝胶镜片长时间佩戴相关的常见并发症。发病时，常从镜片中分离出致病细菌。我们报告一例三次反复发生的浸润性角膜炎病例，其与缺陷乏养菌污染隐形眼镜有关。
一名34岁男性参与水凝胶隐形眼镜长时间佩戴的临床试验，经历了三次浸润性角膜炎发作。使用生物显微镜观察临床表现。每次发病时，无菌取出隐形眼镜，并采集眼拭子进行细菌鉴定和计数。对病情进行监测直至完全消退。
病情的特征为眼刺激、明显的球结膜和角膜缘充血，以及多个局灶性上皮下浸润。许多浸润灶还显示有荧光素染色。在浸润性角膜炎的三次发作中，每次都从隐形眼镜和眼拭子中培养出缺陷乏养菌。
这是首次报道的与隐形眼镜被缺陷乏养菌污染相关的浸润性角膜炎病例。
