Thamer M, Hwang W, Fink N E, Sadler J H, Wills S, Levin N W, Bass E B, Levey A S, Brookmeyer R, Powe N R
Departments of Medicine, Health Policy and Management, Epidemiology, and Biostatistics, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Am J Kidney Dis. 2000 Dec;36(6):1155-65. doi: 10.1053/ajkd.2000.19829.
Selection of a dialysis modality for persons with end-stage renal disease (ESRD) has important lifestyle and occupational implications. The factors affecting modality choice remain unclear, resulting in a low rate of peritoneal dialysis (PD) in the United States compared with other countries. A national survey of 271 US nephrologists was conducted from June 1997 to June 1998 to assess the relative importance of nonclinical and clinical factors related to dialysis modality selection for patients with ESRD. Hypothetical patient scenarios were randomly assigned to nephrologists to determine their recommendation for dialytic therapy based on patient demographic, clinical, and social factors. US nephrologists were more likely to recommend PD for men with ESRD compared with women (39% versus 33%; P: < 0.05; adjusted odds ratio, 1.44; 95% confidence interval, 1.15 to 1.80), as well as for patients with good compliance (adjusted odds ratio, 11.80; 95% confidence interval, 9.29 to 15.01), weight less than 200 lb (adjusted odds ratio, 2.3; 95% confidence interval, 1.8 to 2.9), residual renal function (adjusted odds ratio, 2.14; 95% confidence interval, 1.71 to 2.70), absence of diabetes (adjusted odds ratio, 2.0; 95% confidence interval, 1.6 to 2.5), and living with family (adjusted odds ratio, 1.7; 95% confidence interval, 1.4 to 2.1). Nephrologists in practice for 11 or more years were less likely to recommend PD. The association of male sex with PD therapy suggests a potential bias or sensitivity to women's perception of body image. Race was not associated with PD recommendations after controlling for other demographic and clinical characteristics. Because the incident US ESRD population is increasingly characterized by factors associated with not selecting PD (diabetes, obesity, malnourishment, living alone, and substance abuse problems), our results suggest that PD use may decrease over time.
为终末期肾病(ESRD)患者选择透析方式对其生活方式和职业有重要影响。影响透析方式选择的因素尚不清楚,这导致美国腹膜透析(PD)的使用率与其他国家相比偏低。1997年6月至1998年6月对271名美国肾病学家进行了一项全国性调查,以评估与ESRD患者透析方式选择相关的非临床和临床因素的相对重要性。将假设的患者情况随机分配给肾病学家,以便根据患者的人口统计学、临床和社会因素确定他们对透析治疗的建议。与女性相比,美国肾病学家更倾向于为男性ESRD患者推荐PD(39%对33%;P:<0.05;调整后的优势比为1.44;95%置信区间为1.15至1.80),对于依从性好的患者也是如此(调整后的优势比为11.80;95%置信区间为9.29至15.01),体重低于200磅的患者(调整后的优势比为2.3;95%置信区间为1.8至2.9),有残余肾功能的患者(调整后的优势比为2.14;95%置信区间为1.71至2.70),无糖尿病的患者(调整后的优势比为2.0;95%置信区间为1.6至2.5),以及与家人同住的患者(调整后的优势比为1.7;95%置信区间为1.4至2.1)。从业11年或更长时间的肾病学家不太可能推荐PD。男性与PD治疗之间的关联表明可能存在偏见或对女性身体形象认知的敏感性。在控制了其他人口统计学和临床特征后,种族与PD推荐无关。由于美国新发病的ESRD患者越来越多地具有与不选择PD相关的因素(糖尿病、肥胖、营养不良、独居和药物滥用问题),我们的结果表明,随着时间的推移,PD的使用可能会减少。