Zhai H, Frisch S, Pelosi A, Neibart S, Maibach H I
Department of Dermatology, University of California, San Francisco, Calif., USA.
Skin Pharmacol Appl Skin Physiol. 2000 Nov-Dec;13(6):352-7. doi: 10.1159/000029943.
Few studies evaluate the effect of topical corticosteroids on thermal sensation and in alleviation of itch produced by intradermal injection of histamine. We evaluated the antipruritic effect of hydrocortisone (1% and 2.5%) on histamine-induced itch and sensory effects by measuring itch magnitude, itch duration and thermal thresholds using a computerized thermal sensory analyzer (TSA). This was a double-blind, random, comparative, controlled, single-dose and single-center study. Itch was experimentally induced in both forearms by intracutaneous injection of histamine in 18 subjects. Hydrocortisone 1%, 2.5% and placebo were applied to test sites on both forearms. The thermal threshold for warmth sensation, cold sensation, cold and heat pain was measured with the TSA. Itch magnitude was measured each minute after histamine injection for 10 min with a visual analogue scale (VAS). Itch duration was also recorded. In comparison to placebo, 2.5% hydrocortisone significantly (p = 0.03) reduced itch duration from 12.6 +/- 11.0 min (mean +/- SD) to 8.6 +/- 8.2 min (the reducing rate was 32%) as well as itch magnitude (at minutes 3, 6, 7 and overall). Placebo, 1% and 2.5% hydrocortisone significantly altered (p <0.05) the cold sensation threshold. No treatment altered cold or heat pain thresholds. These data suggest that topical application of 2.5% hydrocortisone may be significantly beneficial for the treatment of histamine-induced itch. The correlation between thermal measurements and antipruritic effects warrants further study.
很少有研究评估局部用皮质类固醇对热感觉以及减轻皮内注射组胺所产生瘙痒的效果。我们通过使用计算机化热感觉分析仪（TSA）测量瘙痒程度、瘙痒持续时间和热阈值，来评估氢化可的松（1%和2.5%）对组胺诱导瘙痒的止痒效果和感觉效应。这是一项双盲、随机、对比、对照、单剂量和单中心研究。通过对18名受试者的双侧前臂皮内注射组胺来实验性诱导瘙痒。将1%、2.5%的氢化可的松和安慰剂分别应用于双侧前臂的测试部位。用TSA测量温暖感觉、冷感觉、冷痛和热痛的热阈值。组胺注射后每分钟用视觉模拟量表（VAS）测量瘙痒程度，持续10分钟。同时记录瘙痒持续时间。与安慰剂相比，2.5%的氢化可的松显著（p = 0.03）缩短了瘙痒持续时间，从12.6 +/- 11.0分钟（平均值 +/- 标准差）降至8.6 +/- 8.2分钟（降低率为32%），并减轻了瘙痒程度（在第3、6、7分钟及总体上）。安慰剂、1%和2.5%的氢化可的松显著改变（p <0.05）了冷感觉阈值。没有治疗方法改变冷痛或热痛阈值。这些数据表明，局部应用2.5%的氢化可的松可能对治疗组胺诱导的瘙痒有显著益处。热测量与止痒效果之间的相关性值得进一步研究。
