Department of Dermatology, School of Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Acta Derm Venereol. 2013 Sep 4;93(5):520-6. doi: 10.2340/00015555-1564.
The aim of this double-blinded, vehicle-controlled study was to test the antipruritic efficacy of topical strontium to relieve a nonhistaminergic form of itch that would be clinically relevant for chronic pruritic diseases. Itch induced with cowhage is mediated by PAR2 receptors which are considered to play a major role in itch of atopic dermatitis and possibly other acute and chronic pruritic conditions. The topical strontium hydrogel formulation (TriCalm®) was tested in a head-to-head comparison with 2 common topical formulations marketed as antipruritics: hydrocortisone and diphenhydramine, for their ability to relieve cowhage-induced itch. Topically-applied strontium salts were previously found to be effective for reducing histamine-induced and IgE-mediated itch in humans. However, histamine is not considered the critical mediator in the majority of skin diseases presenting with chronic pruritus. The current study enrolled 32 healthy subjects in which itch was induced with cowhage before and after skin treatment with a gel containing 4% SrCl2, control vehicle, topical 1% hydrocortisone and topical 2% diphenhydramine. Strontium significantly reduced the peak intensity and duration of cowhage-induced itch when compared to the control itch curve, and was significantly superior to the other two over-the-counter antipruritic agents and its own vehicle in antipruritic effect. We hereby show that a 4% topical strontium formulation has a robust antipruritic effect, not only against histamine-mediated itch, but also for non-histaminergic pruritus induced via the PAR2 pathway, using cowhage.
本双盲、对照研究旨在测试局部锶盐缓解非组胺性瘙痒的止痒疗效，这种瘙痒与慢性瘙痒性疾病相关，且与非组胺有关。荜澄茄素诱导的瘙痒由 PAR2 受体介导，PAR2 受体被认为在特应性皮炎的瘙痒以及其他急性和慢性瘙痒性疾病中起主要作用。我们将 TriCalm®（一种局部锶水凝胶制剂）与两种市售止痒剂（氢化可的松和苯海拉明）进行头对头比较，以评估其缓解荜澄茄素诱导瘙痒的能力。先前的研究发现，局部应用锶盐可有效缓解人类组胺诱导和 IgE 介导的瘙痒。然而，在大多数表现为慢性瘙痒的皮肤病中，组胺并不被认为是关键的介质。本研究共纳入 32 名健康受试者，在皮肤接受含 4% SrCl2 的凝胶、对照载体、1%氢化可的松和 2%苯海拉明局部治疗之前和之后，用荜澄茄素诱导瘙痒。与对照瘙痒曲线相比，锶显著降低了荜澄茄素诱导瘙痒的峰值强度和持续时间，且在止痒效果方面明显优于其他两种非处方止痒剂及其自身载体。我们证明了 4%的局部锶制剂具有强大的止痒作用，不仅对组胺介导的瘙痒有效，而且对通过 PAR2 途径诱导的非组胺性瘙痒也有效。
