Meng Q, Goldberg I D, Rosen E M, Fan S
Department of Radiation Oncology, Long Island Jewish Medical Center, New Hyde Park, New York 11042, USA.
Breast Cancer Res Treat. 2000 Sep;63(2):147-52. doi: 10.1023/a:1006495824158.
Indole-3-carbinol (I3C) is a promising phytochemical agent in chemoprevention of breast cancer. Our present study is the first description of I3C that significantly inhibits the cell adhesion, spreading and invasion associated with an up-regulation of PTEN (a tumor suppressor gene) and E-cadherin (a regulator of cell-cell adhesion) expression in T47-D human breast cancer cells. Therefore, I3C exhibits anti-cancer activities by suppressing breast tumor cell growth and metastatic spread. Metastatic breast cancer is a devastating problem, clinical application of I3C as a potent chemopreventive agent may be helpful in limiting breast cancer invasion and metastasis.
吲哚 - 3 - 甲醇（I3C）是一种在乳腺癌化学预防方面颇具前景的植物化学制剂。我们目前的研究首次描述了I3C能显著抑制T47 - D人乳腺癌细胞中的细胞黏附、铺展和侵袭，同时伴随着肿瘤抑制基因PTEN和细胞间黏附调节因子E - 钙黏蛋白表达上调。因此，I3C通过抑制乳腺肿瘤细胞生长和转移扩散展现出抗癌活性。转移性乳腺癌是一个极具破坏性的问题，将I3C作为一种有效的化学预防剂应用于临床，可能有助于限制乳腺癌的侵袭和转移。
