Monroe M H, Littmann L
Department of Internal Medicine, Carolinas Medical Center, Charlotte, North Carolina 28232-2861, USA.
Clin Cardiol. 2000 Nov;23(11):849-51. doi: 10.1002/clc.4960231112.
Recommendations have recently emerged suggesting that the presence of the Brugada electrocardiographic (ECG) pattern in an otherwise asymptomatic individual warrants electrophysiologic testing for inducible ventricular arrhythmias. However, the prevalence of this pattern in the general population and its specificity for identifying those likely to develop the true Brugada syndrome are not known.
The purpose of this study was to collect ECGs that displayed the Brugada pattern from unselected, noncardiac patients at a single institution to determine whether the implied prevalence in the literature may represent a significant underestimation of the true prevalence.
We performed a prospective case collection of Brugada-patterned ECGs over a 2-year time period from unselected, noncardiac patients at a large urban teaching hospital.
Of approximately 12,000 noncardiac patients, 52 were found to have an ECG pattern fully consistent with the Brugada sign.
The Brugada type ECG pattern is much more prevalent than previously reported when rigorously searched for in a prospective manner. More data are needed on its specificity for predicting future arrhythmic events in asymptomatic individuals before recommendations are made for extensive evaluation in this group.
最近出现的建议表明，在无症状个体中出现Brugada心电图（ECG）模式需要进行电生理检查以检测诱发性室性心律失常。然而，这种模式在普通人群中的患病率及其用于识别可能发展为真正Brugada综合征患者的特异性尚不清楚。
本研究的目的是收集一家机构中未经过挑选的非心脏科患者显示Brugada模式的心电图，以确定文献中隐含的患病率是否可能显著低估了真实患病率。
我们在两年时间内对一家大型城市教学医院未经过挑选的非心脏科患者进行了Brugada模式心电图的前瞻性病例收集。
在大约12000名非心脏科患者中，发现52例患者的心电图模式与Brugada征象完全一致。
以前瞻性方式严格筛查时，Brugada型心电图模式比以前报道的更为普遍。在针对该组人群进行广泛评估提出建议之前，需要更多关于其预测无症状个体未来心律失常事件特异性的数据。
