J.J. Bonica Lecture--2000: Physiology, pathophysiology, and pharmacology of visceral pain.

BACKGROUND AND OBJECTIVES

The principal objective of this report is to review recent experimental advances in our understanding of the physiology and pathophysiology of visceral pain and to describe results of studies of opioid modulation of visceral nociception.

METHODS

Results are drawn from electrophysiological studies of single pelvic nerve afferent fibers innervating the descending colon in the rat.

RESULTS

The important findings include the following: identification of a subset of pelvic nerve fibers that likely function to signal acute visceral pain, sensitization of mechanosensitive pelvic nerve fibers, and documentation of the presence of silent nociceptors in the pelvic nerve. With respect to pharmacological modulation of pelvic nerve fiber responses to colonic distension, only kappa-opioid receptor agonists, and not mu- or delta-opioid receptor agonists, were effective.

CONCLUSIONS

All pelvic nerve fibers innervating the descending colon can be sensitized and contribute to visceral pain; their responses are modulated by kappa-opioid receptor agonists acting in the periphery.