Ho CC, Zydney AL
Department of Chemical Engineering, University of Delaware, Newark, 19716, Delaware
J Colloid Interface Sci. 2000 Dec 15;232(2):389-399. doi: 10.1006/jcis.2000.7231.
Previous studies of protein fouling during microfiltration have shown significant discrepancies between filtrate flux data and predictions of the classical pore blockage, pore constriction, and cake filtration models. A new mathematical model was developed for the filtrate flux which accounts for initial fouling due to pore blockage and subsequent fouling due to the growth of a protein cake or deposit over these initially blocked regions. The model explicitly accounts for the inhomogeneity in the cake layer thickness over different regions of the membrane arising from the time-dependent blockage of the pore surface. The model was shown to be in excellent agreement with experimental data obtained during the stirred cell filtration of bovine serum albumin solutions through polycarbonate track-etched microfiltration membranes over the entire course of the filtration. The model provides a smooth transition from the pore blockage to cake filtration regimes, eliminating the need to use different mathematical formulations to describe these two phenomena. In addition, the model provides the first quantitative explanation for some of the unusual observations reported previously in investigations of protein microfiltration. The results provide important insights into the underlying mechanisms of protein fouling during microfiltration. Copyright 2000 Academic Press.
以往关于微滤过程中蛋白质污染的研究表明，滤液通量数据与经典的孔堵塞、孔收缩和滤饼过滤模型的预测结果之间存在显著差异。针对滤液通量开发了一种新的数学模型，该模型考虑了由于孔堵塞导致的初始污染以及由于蛋白质滤饼或沉积物在这些初始堵塞区域上生长而导致的后续污染。该模型明确考虑了由于孔表面随时间的堵塞而在膜的不同区域上滤饼层厚度的不均匀性。在整个过滤过程中，通过聚碳酸酯径迹蚀刻微滤膜对牛血清白蛋白溶液进行搅拌细胞过滤时获得的实验数据表明，该模型与实验数据非常吻合。该模型提供了从孔堵塞到滤饼过滤状态的平滑过渡，无需使用不同的数学公式来描述这两种现象。此外，该模型首次对先前蛋白质微滤研究中报道的一些异常观察结果进行了定量解释。这些结果为微滤过程中蛋白质污染的潜在机制提供了重要见解。版权所有2000年学术出版社。
