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一种用于模拟蛋白质微滤过程中膜过滤堵塞的新型经验分数方法。

A Novel Empirical Fractional Approach for Modeling the Clogging of Membrane Filtration During Protein Microfiltration.

作者信息

Cherifi Leila, Ammi Yamina, Hanini Salah, Hentabli Mohamed, Belkacem Ouafa, Harmand Jérôme

机构信息

Laboratory of Biomaterials and Transport Phenomena (LBMPT), Faculty of Technology, University Yahia Fares of Medea, Medea 26000, Algeria.

Process Engineering Department, Faculty of Technology, Hassiba Ben Bouali University of Chlef, Hay Essalem, P.O. Box 151, Chlef 02000, Algeria.

出版信息

Membranes (Basel). 2025 Mar 26;15(4):99. doi: 10.3390/membranes15040099.

DOI:10.3390/membranes15040099
PMID:40277969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12029217/
Abstract

This study addresses the pervasive challenge of membrane filtration clogging across various industries. Eight new empirical fractional models are proposed based on the volume accumulation change curve. The effectiveness of these models in predicting material accumulation and characterizing clogging patterns is evaluated. The models are validated against experimental data, achieving impressive coefficients of determination () between 0.9896 and 0.9997 and relative root mean squared errors (nRMSE) ranging from 0.8674% to 2.9548%. Furthermore, comparing the results with theoretical models of Hermia allows us to relate the empirical models to clogging mechanisms.

摘要

本研究解决了膜过滤堵塞在各个行业中普遍存在的挑战。基于体积累积变化曲线提出了八个新的经验分数模型。评估了这些模型在预测物质累积和表征堵塞模式方面的有效性。通过实验数据对模型进行了验证,测定系数()在0.9896至0.9997之间,相对均方根误差(nRMSE)在0.8674%至2.9548%之间,令人印象深刻。此外,将结果与赫米亚的理论模型进行比较,使我们能够将经验模型与堵塞机制联系起来。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11cb/12029217/b21d4c643bc4/membranes-15-00099-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11cb/12029217/afb65bd7e284/membranes-15-00099-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11cb/12029217/f4c1894ceda6/membranes-15-00099-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11cb/12029217/36fcc3b7d29d/membranes-15-00099-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11cb/12029217/b21d4c643bc4/membranes-15-00099-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11cb/12029217/afb65bd7e284/membranes-15-00099-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11cb/12029217/f4c1894ceda6/membranes-15-00099-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11cb/12029217/36fcc3b7d29d/membranes-15-00099-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11cb/12029217/b21d4c643bc4/membranes-15-00099-g005.jpg

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A Novel Empirical Fractional Approach for Modeling the Clogging of Membrane Filtration During Protein Microfiltration.一种用于模拟蛋白质微滤过程中膜过滤堵塞的新型经验分数方法。
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本文引用的文献

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Optimization of MBRs through integrated modelling: A state of the art.通过集成建模优化膜生物反应器:现状
J Environ Manage. 2024 Nov;370:122720. doi: 10.1016/j.jenvman.2024.122720. Epub 2024 Oct 5.
2
Mixed Matrix Membranes Loaded with a Porous Organic Polymer Having Bipyridine Moieties.负载含联吡啶基团多孔有机聚合物的混合基质膜。
Membranes (Basel). 2022 May 25;12(6):547. doi: 10.3390/membranes12060547.
3
Dragonfly Algorithm and Its Hybrids: A Survey on Performance, Objectives and Applications.蜻蜓算法及其混合算法:性能、目标和应用综述。
Sensors (Basel). 2021 Nov 13;21(22):7542. doi: 10.3390/s21227542.
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Structural Identifiability of Dynamic Systems Biology Models.动态系统生物学模型的结构可识别性
PLoS Comput Biol. 2016 Oct 28;12(10):e1005153. doi: 10.1371/journal.pcbi.1005153. eCollection 2016 Oct.
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Three novel approaches to structural identifiability analysis in mixed-effects models.三种新方法用于混合效应模型中的结构可识别性分析。
Comput Methods Programs Biomed. 2019 Apr;171:141-152. doi: 10.1016/j.cmpb.2016.04.024. Epub 2016 May 6.
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Analysis of fouling mechanisms in anaerobic membrane bioreactors.厌氧膜生物反应器中污垢形成机制的分析。
Water Res. 2012 May 15;46(8):2637-50. doi: 10.1016/j.watres.2012.02.021. Epub 2012 Feb 21.
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Robust scale-up of dead end filtration: impact of filter fouling mechanisms and flow distribution.死端过滤的稳健放大:过滤器污垢形成机制和流量分布的影响
Biotechnol Bioeng. 2005 Nov 5;92(3):308-20. doi: 10.1002/bit.20587.
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Predictive QSAR modeling based on diversity sampling of experimental datasets for the training and test set selection.基于实验数据集的多样性采样进行训练集和测试集选择的预测性定量构效关系建模。
J Comput Aided Mol Des. 2002 May-Jun;16(5-6):357-69. doi: 10.1023/a:1020869118689.
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A Combined Pore Blockage and Cake Filtration Model for Protein Fouling during Microfiltration.微滤过程中蛋白质污染的孔堵塞与滤饼过滤组合模型
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