Droller M J, Remington J S
Cancer Res. 1975 Jan;35(1):49-53.
Studies were performed to determine the role of macrophages in inhibition of growth of the same tumor cell type both in vitro and in vivo. Bladder transitional epithelium tumor cells were injected s.c. into Toxoplasma-infected mice, previously shown to contain activated macrophages, and into uninfected controls. The subsequent growth of a solid tumor was significantly less in the Toxoplasma-infected animals. Bladder tumor cells from the same cell line were grown in vitro either alone or in the presence of peritoneal lymphocytes and/or macrophages from oxoplasma-infected and control, uninfected mice. [3H]Thymidine incorporation by the tumor cells was inhibited only in the presence of macrophages from the Toxoplasma-infected animals. Lymphocytes alone did not appear to be cytotoxic under the conditions used. Moreover, lymphocytes from Toxoplasma-infected mice did not convey cytotoxicity to macrophages from control animals under the experimental conditions used.
开展了多项研究以确定巨噬细胞在体外和体内对同一种肿瘤细胞类型生长抑制中的作用。将膀胱移行上皮肿瘤细胞皮下注射到先前已证明含有活化巨噬细胞的弓形虫感染小鼠以及未感染的对照小鼠体内。在弓形虫感染的动物中，实体瘤的后续生长明显较慢。来自同一细胞系的膀胱肿瘤细胞在体外单独培养，或在来自弓形虫感染小鼠和对照未感染小鼠的腹腔淋巴细胞和/或巨噬细胞存在的情况下培养。仅在存在来自弓形虫感染动物的巨噬细胞时，肿瘤细胞的[3H]胸苷掺入才受到抑制。在所使用的条件下，单独的淋巴细胞似乎没有细胞毒性。此外，在所使用的实验条件下，来自弓形虫感染小鼠的淋巴细胞并未将细胞毒性传递给来自对照动物的巨噬细胞。
