卡介苗甲醇提取残渣对豚鼠抗肿瘤免疫的刺激作用
Stimulation of anti-tumour immunity in guinea-pigs by methanol extraction residue of BCG.
作者信息
Wainberg M A, Deutsch V, Weiss D W
出版信息
Br J Cancer. 1976 Nov;34(5):500-8. doi: 10.1038/bjc.1976.204.
Abstract
The immunoprophylactic effects of the methanol extraction residue (MER) of BCG were investigated in Strain 2 guinea-pigs injected with cells of the transplantable, diethylnitrosamine-induced, Line 10 hepatocarcinoma. Pretreatment with MER at times ranging from 18 to 182 days prior to tumour implantation protected approximately 40% of guinea-pigs from progressive neoplastic disease. In addition, MER-treated animals developed specific cell-mediated anti-tumour immunity both more rapidly and at higher levels than did non-MER-treated tumour-bearing controls. It was not possible, however, to prognosticate from the results of such laboratory studies to the outcome of immunoprophylaxis.
摘要
用可移植的、二乙基亚硝胺诱导的10号线肝癌细胞注射2系豚鼠，研究卡介苗甲醇提取残渣（MER）的免疫预防作用。在肿瘤植入前18至182天用MER预处理，约40%的豚鼠免受进行性肿瘤疾病侵害。此外，与未用MER处理的荷瘤对照相比，用MER处理的动物产生特异性细胞介导抗肿瘤免疫的速度更快、水平更高。然而，根据此类实验室研究结果无法预测免疫预防的结果。
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