Russell T A, Rubia K, Bullmore E T, Soni W, Suckling J, Brammer M J, Simmons A, Williams S C, Sharma T
Institute of Psychiatry, King's College, London, UK.
Am J Psychiatry. 2000 Dec;157(12):2040-2. doi: 10.1176/appi.ajp.157.12.2040.
Evidence suggests that patients with schizophrenia have a deficit in "theory of mind," i.e., interpretation of the mental state of others. The authors used functional magnetic resonance imaging (MRI) to investigate the hypothesis that patients with schizophrenia have a dysfunction in brain regions responsible for mental state attribution.
Mean brain activation in five male patients with schizophrenia was compared to that in seven comparison subjects during performance of a task involving attribution of mental state.
During performance of the mental state attribution task, the patients made more errors and showed less blood-oxygen-level-dependent signal in the left inferior frontal gyrus.
To the authors' knowledge, this is the first functional MRI study to show a deficit in the left prefrontal cortex in schizophrenia during a socioemotional task.
有证据表明，精神分裂症患者存在“心理理论”缺陷，即对他人心理状态的解读能力不足。作者使用功能磁共振成像（MRI）来研究精神分裂症患者在负责心理状态归因的脑区存在功能障碍这一假设。
在执行一项涉及心理状态归因的任务时，将5名男性精神分裂症患者的平均脑激活情况与7名对照受试者进行比较。
在执行心理状态归因任务时，患者出现更多错误，且左侧额下回的血氧水平依赖信号较弱。
据作者所知，这是第一项功能磁共振成像研究，显示精神分裂症患者在社会情感任务中左侧前额叶皮质存在缺陷。
