Brunet-Gouet Eric, Decety Jean
Service de Psychiatrie Adulte, Inserm ERI 0015, Hôpital de Versailles, 177 route de Versailles, 78150 Le Chesnay, France.
Psychiatry Res. 2006 Dec 1;148(2-3):75-92. doi: 10.1016/j.pscychresns.2006.05.001. Epub 2006 Nov 7.
Several studies have indicated that schizophrenic patients show impaired performance in various aspects of social cognition, including theory of mind, emotion processing, and agency judgments. Neuroimaging studies that have compared patients and healthy subjects during such mental activity indicate an abnormal hemodynamic response in the medial prefrontal cortex, the prefrontal cortex, the amygdala, the inferior parietal lobe, i.e., a set of regions known to be critically involved in social cognition. This paper addresses a number of issues raised by schizophrenia research into theory of mind, emotion perception and self-agency with regards to the neural systems that mediate social cognition. In healthy subjects, typical brain patterns are associated with theory of mind, emotion perception and self-agency; some activated clusters overlap, while others are distinct. For instance, activations in the paracingulate gyrus are almost systematically associated with theory of mind tasks, while the amygdala is mainly involved in emotion perception tasks. Additional foci are frequently found activated during those tasks: superior temporal sulcus, inferior frontal area. Moreover, the inferior parietal lobe is thought to contribute to agency judgments. In the light of the data on brain abnormalities and neurochemical dysfunctions in schizophrenia, we discuss the interaction of social cognitive dysfunction with the supposed information processing abnormalities caused by dopamine dysregulation.
多项研究表明，精神分裂症患者在社会认知的各个方面表现受损，包括心理理论、情绪加工和能动性判断。在这种心理活动期间比较患者和健康受试者的神经影像学研究表明，内侧前额叶皮质、前额叶皮质、杏仁核、顶下小叶存在异常的血液动力学反应，即已知在社会认知中起关键作用的一组区域。本文探讨了精神分裂症研究中关于心理理论、情绪感知和自我能动性所引发的一些问题，这些问题涉及介导社会认知的神经系统。在健康受试者中，典型的脑模式与心理理论、情绪感知和自我能动性相关；一些激活的簇相互重叠，而另一些则不同。例如，扣带旁回的激活几乎总是与心理理论任务相关，而杏仁核主要参与情绪感知任务。在这些任务期间经常发现其他激活焦点：颞上沟、额下区域。此外，顶下小叶被认为有助于能动性判断。根据精神分裂症中脑异常和神经化学功能障碍的数据，我们讨论了社会认知功能障碍与多巴胺失调导致的假定信息处理异常之间的相互作用。
