Sihvo E I, Salminen J T, Rämö O J, Salo J A
Dept. of Thoracic and Cardiovascular Surgery, HUS, Helsinki University Hospital, Finland.
Scand J Gastroenterol. 2000 Oct;35(10):1082-6. doi: 10.1080/003655200451216.
Owing to overgrowth and definitional problems in classification, the cancer of gastric cardia may affect significantly the epidemiological analysis of oesophageal adenocarcinoma. The purpose of the present study was to evaluate the changes in the incidence of all the adenocarcinomas near the gastrooesophageal junction.
Trends in the incidence rates of adenocarcinoma of the oesophagus and the gastric cardia were described through the Finnish Cancer Registry. The annual age-standardized incidence rates during 1976-95 were analysed by a linear regression technique.
The total incidence of oesophageal carcinoma remained around 3.5/100,000 in men, and decreased from 2.8 to 1.3/100,000 in women. The incidence of oesophageal adenocarcinoma increased from 0.28 to 0.77/100,000 (nearly 300%) in males, and from 0.08 to 0.11 per 100,000 in females. There were no significant changes with time in the incidence rate of gastric cardia cancer in either sex. Combined gastric cardia and oesophageal adenocarcinoma incidence rates remained stable in women, and increased slightly, but significantly, from 2.4 to 2.9/100,000 in men.
Oesophageal adenocarcinoma has increased significantly in men in Finland, but the combined incidence of cancers of the gastro-oesophageal junction has increased only slightly. To overcome the difficulties in classification of oesophageal adenocarcinoma and the cancer of gastric cardia in the epidemiological studies, the focus should be on all adenocarcinomas at or near the oesophagogastric junction.
由于贲门癌的过度生长及分类定义问题，其可能对食管腺癌的流行病学分析产生显著影响。本研究旨在评估胃食管交界附近所有腺癌发病率的变化情况。
通过芬兰癌症登记处描述食管腺癌和贲门癌的发病率趋势。采用线性回归技术分析1976 - 1995年期间的年度年龄标准化发病率。
男性食管癌总发病率维持在约3.5/10万左右，女性则从2.8/10万降至1.3/10万。男性食管腺癌发病率从0.28/10万增至0.77/10万（增长近300%），女性从0.08/10万增至0.11/10万。男女贲门癌发病率随时间均无显著变化。女性贲门癌和食管腺癌合并发病率保持稳定，男性则从2.4/10万略有但显著地增至2.9/10万。
在芬兰，男性食管腺癌发病率显著上升，但胃食管交界癌的合并发病率仅略有增加。为克服流行病学研究中食管腺癌和贲门癌分类的困难，应关注食管胃交界处及附近的所有腺癌。
