通过与OX2（CD200）相互作用下调巨噬细胞谱系。

Down-regulation of the macrophage lineage through interaction with OX2 (CD200).

作者信息

Hoek R M, Ruuls S R, Murphy C A, Wright G J, Goddard R, Zurawski S M, Blom B, Homola M E, Streit W J, Brown M H, Barclay A N, Sedgwick J D

机构信息

DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA 94304, USA.

出版信息

Science. 2000 Dec 1;290(5497):1768-71. doi: 10.1126/science.290.5497.1768.

DOI:10.1126/science.290.5497.1768

PMID:11099416

Abstract

OX2 (CD200) is a broadly expressed membrane glycoprotein, shown here to be important for regulation of the macrophage lineage. In mice lacking CD200, macrophage lineage cells, including brain microglia, exhibited an activated phenotype and were more numerous. Upon facial nerve transection, damaged CD200-deficient neurons elicited an accelerated microglial response. Lack of CD200 resulted in a more rapid onset of experimental autoimmune encephalomyelitis (EAE). Outside the brain, disruption of CD200-CD200 receptor interaction precipitated susceptibility to collagen-induced arthritis (CIA) in mice normally resistant to this disease. Thus, in diverse tissues OX2 delivers an inhibitory signal for the macrophage lineage.

摘要

OX2（CD200）是一种广泛表达的膜糖蛋白，本文显示其对巨噬细胞谱系的调节很重要。在缺乏CD200的小鼠中，包括脑小胶质细胞在内的巨噬细胞谱系细胞表现出活化表型且数量更多。面神经横断后，受损的CD200缺陷神经元引发了加速的小胶质细胞反应。CD200的缺失导致实验性自身免疫性脑脊髓炎（EAE）发病更快。在脑外，CD200-CD200受体相互作用的破坏使通常对这种疾病有抵抗力的小鼠易患胶原诱导的关节炎（CIA）。因此，在不同组织中，OX2为巨噬细胞谱系传递抑制信号。