基因工程改造的低免疫原性人类肌肉祖细胞可减少免疫排斥反应。
Genetically Engineered Hypoimmune Human Muscle Progenitor Cells Can Reduce Immune Rejection.
作者信息
Chen Yu, Wang Peng, Ma Shilin, Yue Chenran, Liu Xupeng, Cheng Yeqian, Liu Kun, Zhao Tongbiao, Shyh-Chang Ng
机构信息
Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
出版信息
Cell Prolif. 2025 Apr;58(4):e13802. doi: 10.1111/cpr.13802. Epub 2025 Jan 7.
Cells face two challenges after transplantation: recognition and killing by lymphocytes, and cell apoptosis induced by the transplantation environment. Our hypoimmune cells aim to address these two challenges through editing of immunomodulatory proteins and overexpression of anti-apoptotic proteins.
移植后的细胞面临两个挑战
被淋巴细胞识别和杀伤，以及由移植环境诱导的细胞凋亡。我们的低免疫原性细胞旨在通过编辑免疫调节蛋白和过表达抗凋亡蛋白来应对这两个挑战。
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