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基因工程改造的低免疫原性人类肌肉祖细胞可减少免疫排斥反应。

Genetically Engineered Hypoimmune Human Muscle Progenitor Cells Can Reduce Immune Rejection.

作者信息

Chen Yu, Wang Peng, Ma Shilin, Yue Chenran, Liu Xupeng, Cheng Yeqian, Liu Kun, Zhao Tongbiao, Shyh-Chang Ng

机构信息

Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.

出版信息

Cell Prolif. 2025 Apr;58(4):e13802. doi: 10.1111/cpr.13802. Epub 2025 Jan 7.

DOI:10.1111/cpr.13802
PMID:39777760
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11969239/
Abstract

Cells face two challenges after transplantation: recognition and killing by lymphocytes, and cell apoptosis induced by the transplantation environment. Our hypoimmune cells aim to address these two challenges through editing of immunomodulatory proteins and overexpression of anti-apoptotic proteins.

摘要

移植后的细胞面临两个挑战

被淋巴细胞识别和杀伤，以及由移植环境诱导的细胞凋亡。我们的低免疫原性细胞旨在通过编辑免疫调节蛋白和过表达抗凋亡蛋白来应对这两个挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca2f/11969239/b34be048fb33/CPR-58-e13802-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca2f/11969239/d2bee415f4aa/CPR-58-e13802-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca2f/11969239/b34be048fb33/CPR-58-e13802-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca2f/11969239/d2bee415f4aa/CPR-58-e13802-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca2f/11969239/b34be048fb33/CPR-58-e13802-g002.jpg

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本文引用的文献

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Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses.妊娠诱导的代谢重编程以及对衰老应激的再生反应。
Trends Endocrinol Metab. 2025 May;36(5):482-494. doi: 10.1016/j.tem.2024.07.011. Epub 2024 Aug 8.
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Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells.乙酰辅酶 A 代谢维持组蛋白乙酰化，以促进人胎盘滋养层干细胞的融合。
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The metabaging cycle promotes non-metabolic chronic diseases of ageing.
代谢衰老循环会引发衰老相关的非代谢性慢性疾病。
Cell Prolif. 2024 Oct;57(10):e13712. doi: 10.1111/cpr.13712. Epub 2024 Jul 11.
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TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons.TNF-NF-κB-p53 轴限制人胚胎干细胞源性多巴胺神经元在体内的存活。
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Immune-privileged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts.免疫豁免组织由免疫伪装的鼠胚胎干细胞形成，可在同种异体宿主中长期存活。
Nat Biomed Eng. 2024 Apr;8(4):427-442. doi: 10.1038/s41551-023-01133-y. Epub 2023 Nov 23.
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Co-expression of HLA-E and HLA-G on genetically modified porcine endothelial cells attenuates human NK cell-mediated degranulation.基因修饰猪内皮细胞共表达 HLA-E 和 HLA-G 可减弱人 NK 细胞介导的脱颗粒作用。
Front Immunol. 2023 Jul 17;14:1217809. doi: 10.3389/fimmu.2023.1217809. eCollection 2023.
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Lin28a maintains a subset of adult muscle stem cells in an embryonic-like state.Lin28a 使一部分成体肌肉干细胞维持在类似胚胎的状态。
Cell Res. 2023 Sep;33(9):712-726. doi: 10.1038/s41422-023-00818-y. Epub 2023 May 15.
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Adult progenitor rejuvenation with embryonic factors.成年祖细胞的胚胎因子再生。
Cell Prolif. 2023 May;56(5):e13459. doi: 10.1111/cpr.13459. Epub 2023 May 12.
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