Green K, Kim K
Invest Ophthalmol. 1975 Jan;14(1):36-40.
Changes in both intraocular pressure and total outflow facility were determined after short- and long-term infusion and topical application of prostaglandin E1 and E2. The intraocular pressure with both routes of administration increased within 15 minutes by 10 to 15 mm. Hg; long-term infusion caused the intraocular pressure to be elevated for a longer time, although a fall in intraocualr pressure occurred despite continued infusion. Total outflow facility did not increase until 30 minutes after initiation of treatment and thereafter increased further with time, irrespective of the route of drug application. The initial increase in intraocular pressure is suggested to be the result of vascular changes, namely an increase in the leakiness of the iris vessels and the capillary pressure of the ciliary body vessels caused by the vasodilatory actions of prostaglandins.
在短期和长期输注以及局部应用前列腺素E1和E2后，测定了眼压和总房水流出易度的变化。两种给药途径的眼压在15分钟内均升高了10至15毫米汞柱；长期输注使眼压升高的时间更长，尽管持续输注时眼压仍出现下降。总房水流出易度直到治疗开始后30分钟才增加，此后随时间进一步增加，与药物应用途径无关。眼压的初始升高被认为是血管变化的结果，即前列腺素的血管舒张作用导致虹膜血管渗漏增加和睫状体血管毛细血管压力增加。
