利奈唑胺在兔脑膜炎模型中对青霉素敏感和耐药肺炎球菌的作用
Linezolid against penicillin-sensitive and -resistant pneumococci in the rabbit meningitis model.
作者信息
Cottagnoud P, Gerber C M, Acosta F, Cottagnoud M, Neftel K, Täuber M G
机构信息
Department of Internal Medicine, Inselspital, Freiburgstrasse, 3010 Berne, Switzerland.
出版信息
J Antimicrob Chemother. 2000 Dec;46(6):981-5. doi: 10.1093/jac/46.6.981.
Linezolid, a new oxazolidinone antibiotic, showed good penetration (38+/-4%) into the meninges of rabbits with levels in the CSF ranging from 9.5 to 1.8 mg/L after two i.v. injections (20 mg/kg). Linezolid was clearly less effective than ceftriaxone against a penicillin-sensitive pneumococcal strain. Against a penicillin-resistant strain, linezolid had slightly inferior killing rates compared with the standard regimen (ceftriaxone combined with vancomycin). In vitro, linezolid was marginally bactericidal at concentrations above the MIC (5 x and 10 x MIC).
利奈唑胺是一种新型恶唑烷酮类抗生素，在给家兔静脉注射两次（20mg/kg）后，它在兔脑膜中显示出良好的穿透性（38±4%），脑脊液中的浓度范围为9.5至1.8mg/L。在针对青霉素敏感肺炎球菌菌株方面，利奈唑胺的效果明显不如头孢曲松。在针对青霉素耐药菌株时，与标准治疗方案（头孢曲松联合万古霉素）相比，利奈唑胺的杀菌率略低。在体外，当浓度高于最低抑菌浓度（5倍和10倍最低抑菌浓度）时，利奈唑胺具有微弱的杀菌作用。
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