Obregon Demian, Parker-Athill Ellisa Carla, Tan Jun, Murphy Tanya
Department of Psychiatry & Behavioral Neurosciences, University of South Florida, Morsani College of Medicine, Tampa, FL, USA ; Silver Child Development Center, Department of Psychiatry & Behavioral Neurosciences, University of South Florida, Morsani College of Medicine, Tampa, FL, USA.
Neuropsychiatry (London). 2012 Aug;2(4):331-343. doi: 10.2217/npy.12.41.
Antimicrobial compounds and psychotropic medications often share overlapping mechanisms of actions and pharmacological effects. The immune system appears to be an important site of interaction as several antimicrobials display neurological and, at times, direct psychotropic effects, while psychotropics have shown significant immunomodulatory properties. The isoniazid class of antibiotics for example has been shown to possess monoamine oxidase activity, while selective serotonin reuptake inhibitors have shown significant effects on leukocyte populations. As the importance of the immune system's role in CNS homeostasis and disease continues to move to the forefront of neuropsychiatric research, these shared pharmacological effects may provide an important insight, elucidating the complexities in neuroimmune pathophysiology and guiding the development of potential treatments.
抗菌化合物和精神药物通常具有重叠的作用机制和药理效应。免疫系统似乎是一个重要的相互作用位点，因为几种抗菌药物具有神经学效应，有时还具有直接的精神效应，而精神药物已显示出显著的免疫调节特性。例如，异烟肼类抗生素已被证明具有单胺氧化酶活性，而选择性5-羟色胺再摄取抑制剂已显示出对白细胞群体有显著影响。随着免疫系统在中枢神经系统稳态和疾病中的作用的重要性不断成为神经精神研究的前沿，这些共同的药理效应可能提供重要的见解，阐明神经免疫病理生理学的复杂性，并指导潜在治疗方法的开发。
