在巴布亚新几内亚患有急性细菌性脑膜炎的儿童的肺炎链球菌分离株中，氯霉素耐药性增加。
Increasing chloramphenicol resistance in Streptococcus pneumoniae isolates from Papua New Guinean children with acute bacterial meningitis.
机构信息
School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia.
出版信息
Antimicrob Agents Chemother. 2011 Sep;55(9):4454-6. doi: 10.1128/AAC.00526-11. Epub 2011 Jun 27.
Abstract
In Papua New Guinean (PNG) children with acute bacterial meningitis (ABM), all Haemophilus influenzae isolates were resistant to chloramphenicol. Although Streptococcus pneumoniae isolates had a median chloramphenicol MIC of 3 μg/ml, it was ≥4 μg/ml in 42.8%, and the likelihood of an area under the 24-hour concentration-time curve/MIC ratio of >100 h at a MIC of ≥4 μg/ml was approximately 50%. All isolates were ceftriaxone sensitive. These data support ceftriaxone rather than conventional chloramphenicol for all PNG children with suspected ABM.
摘要
在巴布亚新几内亚（PNG）患有急性细菌性脑膜炎（ABM）的儿童中，所有流感嗜血杆菌分离株均对氯霉素耐药。虽然肺炎链球菌分离株的氯霉素 MIC 中位数为 3μg/ml，但有 42.8%的分离株的 MIC 为≥4μg/ml，在 MIC 为≥4μg/ml 时，24 小时浓度-时间曲线下面积/ MIC 比值>100 h 的可能性约为 50%。所有分离株均对头孢曲松敏感。这些数据支持对所有疑似患有 ABM 的 PNG 儿童使用头孢曲松，而不是传统的氯霉素。
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