Herz U, Lacy P, Renz H, Erb K
Department of Clinical Chemistry and Molecular Diagnostics, Central Laboratory, Hospital of the Philipps University, 35033 Baldingerstrasse, Marburg, Germany.
Curr Opin Immunol. 2000 Dec;12(6):632-40. doi: 10.1016/s0952-7915(00)00155-2.
The frequency and severity of atopic disorders are steadily increasing, particularly in developing countries. The reason for this observation is not clear. Recent studies indicate that infections with viruses and especially with bacteria early in life may help to inhibit allergic Th2 responses by skewing the immune system towards Th1 responses. However, infections can also lead to the exacerbation of atopic disorders.
特应性疾病的发病率和严重程度正在稳步上升，尤其是在发展中国家。这一现象的原因尚不清楚。最近的研究表明，生命早期感染病毒，尤其是细菌，可能通过使免疫系统偏向Th1反应来帮助抑制过敏性Th2反应。然而，感染也可能导致特应性疾病的加重。
