Fugger L
Department of Clinical Immunology, Aarhus University Hospital, Skejby Sygehus, DK-8200 N, Aarhus, Denmark.
Curr Opin Immunol. 2000 Dec;12(6):698-703. doi: 10.1016/s0952-7915(00)00165-5.
In the post-genomic era, the expression and investigation of human (auto)immunity genes seems more relevant than ever. The generation of humanized animal models of human diseases will be useful to study the interplay between genetic and non-genetic factors in disease development and may form a basis for the development of new drugs that act more specifically than the ones currently in use. Transgenic mice have been generated that express various human proteins--candidate autoantigens, disease-associated MHC class II molecules, TCRs and/or CD4--in order to study diseases such as rheumatoid arthritis, multiple sclerosis and diabetes.
在后基因组时代，人类（自身）免疫基因的表达和研究似乎比以往任何时候都更为重要。人类疾病人源化动物模型的建立将有助于研究疾病发展过程中遗传和非遗传因素之间的相互作用，并可能为开发比目前使用的药物作用更具特异性的新药奠定基础。为了研究类风湿性关节炎、多发性硬化症和糖尿病等疾病，已经培育出了表达各种人类蛋白质（候选自身抗原、疾病相关的II类主要组织相容性复合体分子、T细胞受体和/或CD4）的转基因小鼠。
