Mocci S, Lafferty K, Howard M
Division of Autoimmune Disease, Corixa, 301 Penobscot Drive, Redwood City, CA 94603, USA.
Curr Opin Immunol. 2000 Dec;12(6):725-30. doi: 10.1016/s0952-7915(00)00169-2.
Many autoantigens have been identified in human patients and in rodent models. In numerous experimental settings, these autoantigens or related autoreactive lymphocytes can transfer autoimmunity. Although autoreactivity spreads to new epitopes during the course of disease, single-epitope-specific therapies show considerable efficacy in multi-epitope-induced models of autoimmunity. These observations may indicate that epitope-specific therapies operate at the level of regulating mechanisms of immune tolerance rather than exerting a direct effect on autoreactive T lymphocytes.
在人类患者和啮齿动物模型中已鉴定出许多自身抗原。在众多实验环境中，这些自身抗原或相关的自身反应性淋巴细胞可传递自身免疫性。尽管在疾病过程中自身反应性会扩散到新的表位，但单表位特异性疗法在多表位诱导的自身免疫模型中显示出相当大的疗效。这些观察结果可能表明，表位特异性疗法作用于免疫耐受调节机制层面，而非对自身反应性T淋巴细胞产生直接影响。
