[食管癌的术后辅助治疗]
[Postoperative adjuvant therapies for esophageal carcinoma].
作者信息
Kuwano H, Ojima H, Kato H
机构信息
First Dept. of Surgery, Gunma University School of Medicine, Japan.
出版信息
Gan To Kagaku Ryoho. 2000 Nov;27(13):2023-7.
Recent studies have focused on biochemical modulation with the combined use of CDDP and 5-FU for esophageal cancer. The combination of chemo- and radiotherapy is one of the most effective regimens for esophageal carcinoma. This combination therapy led to complete clinical remission in up to 30% of the cases in a prospective randomized study. We introduce many trials about postoperative adjuvant therapy after surgical treatment for esophageal carcinoma. The development and investigation of more effective chemotherapy regimens, as well as precise assessments of the response to preoperative treatment, is the challenge for randomized trials in the future.
最近的研究集中在顺铂（CDDP）和氟尿嘧啶（5-FU）联合用于食管癌的生化调节方面。化疗和放疗联合是食管癌最有效的治疗方案之一。在一项前瞻性随机研究中，这种联合治疗在高达30%的病例中实现了完全临床缓解。我们介绍了许多关于食管癌手术治疗后术后辅助治疗的试验。开发和研究更有效的化疗方案，以及精确评估术前治疗的反应，是未来随机试验面临的挑战。
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