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5-methyltetrahydrofolic acid is not a methyl donor for biogenic amines: enzymatic formation of formaldehyde.

作者信息

Meller E, Rosengarten H, Friedhoff A J, Stebbins R D, Silber R

出版信息

Science. 1975 Jan 17;187(4172):171-3. doi: 10.1126/science.1111095.

DOI:10.1126/science.1111095
PMID:1111095
Abstract

Contrary to previous reports, 5-methyltetrahydrofolic acid does not mediate the methylation of dopamine to epinine. Instead, this methyl donor is degraded enzymatically to formaldehyde, which condenses with dopamine to form a tetahydoisoquinoline derivative. The latter has chromotographic characteristics very similar to those of epinine, which likely accounts for the original misidentification of the product.

摘要

相似文献

1
5-methyltetrahydrofolic acid is not a methyl donor for biogenic amines: enzymatic formation of formaldehyde.
Science. 1975 Jan 17;187(4172):171-3. doi: 10.1126/science.1111095.
2
N-methylation of dopamine to epinine in brain tissue using N-methyltetrahydrofolic acid as the methyl donor.利用N-甲基四氢叶酸作为甲基供体，在脑组织中将多巴胺N-甲基化为去甲肾上腺素。
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Synthesis of tetrahydro-beta-carbolines from indoleamines via enzymatic formation of formaldehyde from 5-methyltetrahydrofolic acid.通过5-甲基四氢叶酸酶促形成甲醛，由吲哚胺合成四氢-β-咔啉。
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N-methylation of biogenic amines. I. Characterization and properties of an N-methyltransferase in rat brain using 5-methyltetrahydrofolic acid as the methyl donor.生物胺的N-甲基化。I. 以5-甲基四氢叶酸作为甲基供体时大鼠脑中N-甲基转移酶的特性和性质。
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Methyltetrahydrofolic acid mediates N- and O-methylation of biogenic amines.
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N-methyltetrahydrofolic acid: the physiological methyl donor in indoleamine N- and O-methylation.N-甲基四氢叶酸：吲哚胺N-甲基化和O-甲基化中的生理性甲基供体。
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Enzymatic formaldehyde production from 5-methyltetrahydrofolic acid: prior step to alkaloid formation.由5-甲基四氢叶酸通过酶促反应生成甲醛：生物碱形成的前期步骤。
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Evidence for the absence of amine-N-methylation and O-methylation in indolethylamines with methyltetrahydrofolic acid-dependent N-methyltransferase.关于吲哚乙胺中不存在胺 - N - 甲基化和O - 甲基化以及依赖甲基四氢叶酸的N - 甲基转移酶的证据。
Res Commun Chem Pathol Pharmacol. 1974 Jul;8(3):535-42.
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Identification of alkaloids; the condensation products of biogenic amines with formaldehyde, enzymatically formed from 5-methyltetrahydrofolic acid.生物碱的鉴定；生物胺与甲醛的缩合产物，由5-甲基四氢叶酸酶促形成。
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N-methylation of indolealkylamines in the brain with a new methyl donor.使用新型甲基供体对大脑中吲哚烷基胺进行N-甲基化。
Adv Biochem Psychopharmacol. 1974;11(0):65-74.

引用本文的文献

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Methyl Metabolism and the Clock: An Ancient Story With New Perspectives.甲基化代谢与生物钟：一个具有新视角的古老故事。
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2
Drugs and folate metabolism.药物与叶酸代谢
Drugs. 1985 Aug;30(2):145-55. doi: 10.2165/00003495-198530020-00003.
3
Lack of epinine formation in adrenal medulla and brain of rats during cold exposure and inhibition of dopamine beta-hydroxylase.冷暴露期间大鼠肾上腺髓质和脑中去甲肾上腺素形成的缺乏以及多巴胺β-羟化酶的抑制作用
Naunyn Schmiedebergs Arch Pharmacol. 1976 May;293(2):139-44. doi: 10.1007/BF00499218.
4
Tetrahydronorharmane (tetrahydro-beta-carboline), a physiologically occurring compound of indole metabolism.四氢去甲哈尔满（四氢-β-咔啉），一种吲哚代谢过程中自然产生的化合物。
Naunyn Schmiedebergs Arch Pharmacol. 1978 Nov;305(2):135-41. doi: 10.1007/BF00508283.
5
Pathology of folate deficiency.叶酸缺乏的病理学
Proc R Soc Med. 1977 Feb;70(2):82-4. doi: 10.1177/003591577707000206.
6
6-Hydroxy-tetrahydronorharmane (6-hydroxy-tetrahydro-beta-carboline), a new active metabolite of indole-alkylamines in man and rat.6-羟基-四氢去甲哈尔满（6-羟基-四氢-β-咔啉），一种人和大鼠体内吲哚烷基胺的新型活性代谢产物。
Naunyn Schmiedebergs Arch Pharmacol. 1979 Dec;310(1):35-41. doi: 10.1007/BF00499872.
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Folate metabolism in the superior cervical ganglion histochemical study.颈上神经节中叶酸代谢的组织化学研究。
Histochemistry. 1979 Jul;62(1):101-7. doi: 10.1007/BF00537011.
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Inhibition of 5-hydroxytryptamine uptake by tetrahydronorharmane in vivo.体内四氢去甲哈尔满对5-羟色胺摄取的抑制作用。
Naunyn Schmiedebergs Arch Pharmacol. 1978 Jul;303(3):229-33. doi: 10.1007/BF00498048.