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Methyltetrahydrofolic acid mediates N- and O-methylation of biogenic amines.

作者信息

Banerjee S P, Snyder S H

出版信息

Science. 1973 Oct 5;182(4107):74-5. doi: 10.1126/science.182.4107.74.

DOI:10.1126/science.182.4107.74
PMID:4581052
Abstract

A variety of mammalian and avian tissues N- and O-methylate indoleamines and phenylethylamines, with methyltetrahydrofolic acid as the methyl donor. Because it is considerably more efficient than S-adenosylmethionine, methyltetrahydrofolic acid may be the natural methyl donor in this reaction. With methyltetrahydrofolic acid, serotonin is O-methylated to 5-methoxytryptamine, a novel indoleamine in mammalian brain.

摘要

相似文献

1
Methyltetrahydrofolic acid mediates N- and O-methylation of biogenic amines.
Science. 1973 Oct 5;182(4107):74-5. doi: 10.1126/science.182.4107.74.
2
N-methyltetrahydrofolic acid: the physiological methyl donor in indoleamine N- and O-methylation.N-甲基四氢叶酸：吲哚胺N-甲基化和O-甲基化中的生理性甲基供体。
Adv Biochem Psychopharmacol. 1974;11(0):85-93.
3
Evidence for the absence of amine-N-methylation and O-methylation in indolethylamines with methyltetrahydrofolic acid-dependent N-methyltransferase.关于吲哚乙胺中不存在胺 - N - 甲基化和O - 甲基化以及依赖甲基四氢叶酸的N - 甲基转移酶的证据。
Res Commun Chem Pathol Pharmacol. 1974 Jul;8(3):535-42.
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N-methylation of dopamine to epinine in brain tissue using N-methyltetrahydrofolic acid as the methyl donor.利用N-甲基四氢叶酸作为甲基供体，在脑组织中将多巴胺N-甲基化为去甲肾上腺素。
Nat New Biol. 1972 Aug 16;238(85):212-3. doi: 10.1038/newbio238212a0.
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N-methylation of biogenic amines. I. Characterization and properties of an N-methyltransferase in rat brain using 5-methyltetrahydrofolic acid as the methyl donor.生物胺的N-甲基化。I. 以5-甲基四氢叶酸作为甲基供体时大鼠脑中N-甲基转移酶的特性和性质。
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Synthesis of tetrahydro-beta-carbolines from indoleamines via enzymatic formation of formaldehyde from 5-methyltetrahydrofolic acid.通过5-甲基四氢叶酸酶促形成甲醛，由吲哚胺合成四氢-β-咔啉。
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N-methylation of indolealkylamines in the brain with a new methyl donor.使用新型甲基供体对大脑中吲哚烷基胺进行N-甲基化。
Adv Biochem Psychopharmacol. 1974;11(0):65-74.
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5-methyltetrahydrofolic acid is not a methyl donor for biogenic amines: enzymatic formation of formaldehyde.
Science. 1975 Jan 17;187(4172):171-3. doi: 10.1126/science.1111095.
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A review of recent studies of the biosynthesis and excretion of hallucinogens formed by methylation of neurotransmitters or related substances.
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Indoleamine-N-methyl transferase in human lung.人肺中的吲哚胺-N-甲基转移酶
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