通过5-甲基四氢叶酸酶促形成甲醛，由吲哚胺合成四氢-β-咔啉。 - Suppr | 超能文献

Synthesis of tetrahydro-beta-carbolines from indoleamines via enzymatic formation of formaldehyde from 5-methyltetrahydrofolic acid.

作者信息

Rosengarten H, Meller E, Friedhoff A J

出版信息

Biochem Pharmacol. 1975 Oct 1;24(19):1759-62. doi: 10.1016/0006-2952(75)90452-9.

DOI:10.1016/0006-2952(75)90452-9

Abstract

摘要

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Synthesis of tetrahydro-beta-carbolines from indoleamines via enzymatic formation of formaldehyde from 5-methyltetrahydrofolic acid.通过5-甲基四氢叶酸酶促形成甲醛，由吲哚胺合成四氢-β-咔啉。

Biochem Pharmacol. 1975 Oct 1;24(19):1759-62. doi: 10.1016/0006-2952(75)90452-9.

2

Evidence for the absence of amine-N-methylation and O-methylation in indolethylamines with methyltetrahydrofolic acid-dependent N-methyltransferase.关于吲哚乙胺中不存在胺 - N - 甲基化和O - 甲基化以及依赖甲基四氢叶酸的N - 甲基转移酶的证据。

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4

5-methyltetrahydrofolic acid is not a methyl donor for biogenic amines: enzymatic formation of formaldehyde.

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Enzymatic formation of tetrahydro-beta-carboline from tryptamine and 5-methyltetrahydrofolic acid in rat brain fractions: regional and subcellular distribution.大鼠脑匀浆中色胺和5-甲基四氢叶酸酶促形成四氢-β-咔啉：区域及亚细胞分布

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N-methyltetrahydrofolic acid: the physiological methyl donor in indoleamine N- and O-methylation.N-甲基四氢叶酸：吲哚胺N-甲基化和O-甲基化中的生理性甲基供体。

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Methyltetrahydrofolic acid mediates N- and O-methylation of biogenic amines.

Science. 1973 Oct 5;182(4107):74-5. doi: 10.1126/science.182.4107.74.

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Conversion of C14-S-adenosylmethionine to C14-formaldehyde and condensation with indoleamines: a side reaction in N-methyltransferase assay in blood.C14-S-腺苷甲硫氨酸转化为C14-甲醛并与吲哚胺缩合：血液中N-甲基转移酶测定中的一种副反应。

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A possible mechanism for the antischizophrenic action of chlorpromazine: inhibition of the formation of dimethyltryptamine by chlorpromazine metabolites.氯丙嗪抗精神分裂症作用的一种可能机制：氯丙嗪代谢产物对二甲基色胺形成的抑制作用。

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Enzymatic formaldehyde production from 5-methyltetrahydrofolic acid: prior step to alkaloid formation.由5-甲基四氢叶酸通过酶促反应生成甲醛：生物碱形成的前期步骤。

Biochem Pharmacol. 1975 Apr 15;24(8):929-32. doi: 10.1016/0006-2952(75)90171-9.

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Endocrine effects of 5-methoxytryptoline, 5-hydroxytryptoline and tryptoline, putative modulators of rat serotonergic system.5-甲氧基色胺、5-羟色胺和色胺对大鼠血清素能系统的假定调节剂的内分泌作用。

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Conditions for the formation of cyclic compounds between pyridoxal phosphate and 5-hydroxytryptamine or 5-hydroxytryptophan.磷酸吡哆醛与5-羟色胺或5-羟色氨酸之间形成环状化合物的条件。

Agents Actions. 1978 Apr;8(3):185-90. doi: 10.1007/BF01966601.