Lerner R G, Nelson J, Sorcia E, Grima K, Kancherla R R, Zarou-Naimo C M, Pehta J C
Hematology Section, Department of Medicine, Valhalla, N.Y., USA.
Vox Sang. 2000;79(3):161-7. doi: 10.1159/000031235.
To compare the laboratory and clinical outcome of patients who received solvent/detergent-treated plasma (SDP) and fresh-frozen plasma (FFP).
A randomized, double-blinded study to assess the ability of SDP and FFP to reduce a prolonged prothrombin time (PT) to </=15 s in patients with acquired coagulation deficits.
45 patients (22 SDP vs. 23 FFP) were treated with 71 infusions. There were no significant differences in mean dose of plasma infused (7.8 ml/kg for SDP vs. 8.0 ml/kg for FFP, p = 0.46), percentage of patients who corrected their PT to </=15 s (32% for SDP vs. 26% for FFP, p = 0.67), or percentage of patients whose bleeding ceased (27% for SDP vs. 22% for FFP).
No clinical or statistically significant differences were observed after infusion with SDP or FFP in patients with acquired coagulation deficits.
比较接受溶剂/去污剂处理血浆（SDP）和新鲜冰冻血浆（FFP）的患者的实验室检查结果和临床结局。
一项随机双盲研究，评估SDP和FFP在获得性凝血功能缺陷患者中将延长的凝血酶原时间（PT）降至≤15秒的能力。
45例患者（22例接受SDP，23例接受FFP）接受了71次输注。输注血浆的平均剂量（SDP为7.8 ml/kg，FFP为8.0 ml/kg，p = 0.46）、PT校正至≤15秒的患者百分比（SDP为32%，FFP为26%，p = 0.67）或出血停止的患者百分比（SDP为27%，FFP为22%）均无显著差异。
在获得性凝血功能缺陷患者中，输注SDP或FFP后未观察到临床或统计学上的显著差异。
