凝血酶原时间延长患者中溶剂/去污剂处理血浆的评估

Evaluation of solvent/detergent-treated plasma in patients with a prolonged prothrombin time.

作者信息

Lerner R G, Nelson J, Sorcia E, Grima K, Kancherla R R, Zarou-Naimo C M, Pehta J C

机构信息

Hematology Section, Department of Medicine, Valhalla, N.Y., USA.

出版信息

Vox Sang. 2000;79(3):161-7. doi: 10.1159/000031235.

DOI:10.1159/000031235

PMID:11111235

Abstract

OBJECTIVES

To compare the laboratory and clinical outcome of patients who received solvent/detergent-treated plasma (SDP) and fresh-frozen plasma (FFP).

METHODS

A randomized, double-blinded study to assess the ability of SDP and FFP to reduce a prolonged prothrombin time (PT) to </=15 s in patients with acquired coagulation deficits.

RESULTS

45 patients (22 SDP vs. 23 FFP) were treated with 71 infusions. There were no significant differences in mean dose of plasma infused (7.8 ml/kg for SDP vs. 8.0 ml/kg for FFP, p = 0.46), percentage of patients who corrected their PT to </=15 s (32% for SDP vs. 26% for FFP, p = 0.67), or percentage of patients whose bleeding ceased (27% for SDP vs. 22% for FFP).

CONCLUSION

No clinical or statistically significant differences were observed after infusion with SDP or FFP in patients with acquired coagulation deficits.

摘要

目的

比较接受溶剂/去污剂处理血浆（SDP）和新鲜冰冻血浆（FFP）的患者的实验室检查结果和临床结局。

方法

一项随机双盲研究，评估SDP和FFP在获得性凝血功能缺陷患者中将延长的凝血酶原时间（PT）降至≤15秒的能力。

结果

45例患者（22例接受SDP，23例接受FFP）接受了71次输注。输注血浆的平均剂量（SDP为7.8 ml/kg，FFP为8.0 ml/kg，p = 0.46）、PT校正至≤15秒的患者百分比（SDP为32%，FFP为26%，p = 0.67）或出血停止的患者百分比（SDP为27%，FFP为22%）均无显著差异。