Engst R, Erhardt V, Kujawa M, Macholz R M, Pfaff K, Woggon H
Nahrung. 1979;23(3):303-17. doi: 10.1002/food.19790230316.
Whole blood samples from 40 male and 40 female individuals were analyzed for zinc, copper, selenium and iron, and in part also for cadmium and lead. Correlations were established between the element contents and the activities of blood enzymes (carbo-anhydrase, leucine aminopeptidase, lactate dehydrogenase, alkaline phosphatase, glutathione peroxidase). The zinc-copper ratio exerted no effect on the zinc-dependent enzymes. There was a correlation between the glutathione peroxidase activity and the selenium content in whole blood (r greater than 0.73). A cluster analysis was performed. In women, the authors stated a significant effect of oral contraceptives especially on the zinc and copper balance. It was evidenced that detectable (more marked) changes in the mineral equilibrium are not produced in all cases by the contraceptives. Nevertheless, changes in the mineral equilibrium are likely to occur in 25% of all women. In the present study further changes (for example in enzymes) were observed in 50% of all women. The results obtained from the male individuals were indicative of certain relationships between the zinc-copper ratio and the content of total lipids or lipid fractions in human blood.
对40名男性和40名女性的全血样本进行了锌、铜、硒和铁的分析，部分还分析了镉和铅。建立了元素含量与血液酶（碳酸酐酶、亮氨酸氨肽酶、乳酸脱氢酶、碱性磷酸酶、谷胱甘肽过氧化物酶）活性之间的相关性。锌铜比对锌依赖性酶没有影响。全血中谷胱甘肽过氧化物酶活性与硒含量之间存在相关性（r大于0.73）。进行了聚类分析。作者指出，口服避孕药对女性有显著影响，尤其是对锌和铜的平衡。有证据表明，避孕药并非在所有情况下都会导致可检测到的（更明显的）矿物质平衡变化。然而，矿物质平衡变化可能发生在25%的女性中。在本研究中，50%的女性出现了进一步的变化（如酶的变化）。从男性个体获得的结果表明，锌铜比与人体血液中总脂质或脂质组分含量之间存在一定关系。
