Hasday J D, Garrison A
Medical Care Clinical Center, Veterans Affairs Maryland Health Care System, Baltimore, MD 21201, USA.
Clin Infect Dis. 2000 Oct;31 Suppl 5:S234-41. doi: 10.1086/317514.
Sepsis is a clinical syndrome characterized by a systemic inflammatory response to infection. Mortality rates in sepsis have remained high, despite recent advances in our understanding of the immunological mechanisms that cause sepsis. Fever, a nonspecific acute-phase response, has been associated with improved survival and shortened disease duration in some infections. This article reviews the biological effects of fever and the influence of antipyretic therapy on the outcome in sepsis in experimental models and in humans and offers clinical recommendations for antipyretic therapy in early and late stages of the disorder.
脓毒症是一种由对感染的全身性炎症反应所表征的临床综合征。尽管我们对导致脓毒症的免疫机制的理解最近有所进展，但脓毒症的死亡率仍然很高。发热是一种非特异性急性期反应，在某些感染中与生存率提高和病程缩短有关。本文综述了发热的生物学效应以及退热治疗对实验模型和人类脓毒症预后的影响，并针对该病症早期和晚期的退热治疗提供临床建议。
