Cimadevilla J M, Garcia Moreno L M, Gonzalez Pardo H, Zahonero M C, Arias J L
Laboratory of Psychobiology, Facultad de Psicología, Universidad de Oviedo, Spain.
Mech Ageing Dev. 1997 Dec 1;99(1):49-60. doi: 10.1016/s0047-6374(97)00090-0.
Stereological methods (neuron and glial cell numbers) and histochemical methods (cytochrome c oxidase) were used to study postnatal development and aging of the CA1 and CA3 hippocampal areas in male rats. No changes were observed in 10 microns sections in the neuronal population of areas CA1 and CA3 in any of the groups (14 days, 21 days, adult-90 days and elderly-22 months). Statistical differences were found in the number of glial cells in both the CA1 and CA3 areas. An increase was observed in cytochrome oxidase (CO) activity in the CA1 area in the 14 day old rats compared to the other groups while in area CA3 this parameter increased in the 14 and 21 day old groups and the group of adult rats. No significant changes in CO activity were found in the elderly rats in both areas. These results are discussed in the light of those recorded in other areas of the limbic system.
采用体视学方法（神经元和胶质细胞数量）和组织化学方法（细胞色素c氧化酶）研究雄性大鼠海马CA1区和CA3区的出生后发育及衰老情况。在任何组（14天、21天、成年-90天和老年-22个月）的CA1区和CA3区神经元群体中，10微米切片均未观察到变化。在CA1区和CA3区的胶质细胞数量上发现了统计学差异。与其他组相比，14日龄大鼠的CA1区细胞色素氧化酶（CO）活性增加，而在CA3区，该参数在14日龄和21日龄组以及成年大鼠组中增加。老年大鼠在这两个区域的CO活性均未发现显著变化。根据在边缘系统其他区域记录的结果对这些结果进行了讨论。
