Guerrero-Romero F, Rodríguez-Morán M
Medical Research Unit in Clinical Epidemiology, Durango, Mexico.
J Diabetes Complications. 2000 Sep-Oct;14(5):272-6. doi: 10.1016/s1056-8727(00)00127-6.
Hypomagnesemia is common in diabetic subjects, and is especially common in poorly controlled diabetes, suggesting that diabetes low serum magnesium status is osmotic diuresis-dependent. To assess the relationship between serum magnesium and HDL-cholesterol concentration adjusted by serum glucose values. We assessed the serum magnesium levels of 50 controlled (HbA(1c)</=7.5% and FPG<126 mg/dl), 110 non-controlled (HbA(1c)>7.5% and FPG>/=126 mg/dl) type II diabetic patients, 40 subjects with impaired fasting glucose (IFG) (FPG>/=110 mg/dl and <126 mg/dl) and 190 healthy volunteers (FPG<110 mg/dl). Healthy volunteers were required to have normal blood pressure and normal laboratory tests. Subjects in the groups included were matched by age and body mass index (BMI). The average of diabetes duration was of 11.4+/-6.6, and 10.9+/-6.2 years, P=NS, for the controlled and non-controlled diabetic patients, respectively. Thirty (60.0%) controlled diabetic subjects, 58 (52. 7%) non-controlled diabetic patients, 21 (52.5%) subjects with IFG, and 39 (20.5%) healthy volunteers had serum magnesium levels </=1.7 mg/l. Serum HDL-cholesterol value showed significant graded increase with serum magnesium levels irrespective of glucose values. Results of this study suggest that hypomagnesemia by an etiopathogenic pathway glycemia independent seems to be involved to decrease HDL-cholesterol.
低镁血症在糖尿病患者中很常见，在血糖控制不佳的糖尿病患者中尤其常见，这表明糖尿病患者血清镁水平降低与渗透性利尿有关。为了评估血清镁与经血清葡萄糖值校正的高密度脂蛋白胆固醇浓度之间的关系。我们评估了50例血糖控制良好（糖化血红蛋白[HbA(1c)]≤7.5%且空腹血糖[FPG]<126mg/dl）、110例血糖未控制（HbA(1c)>7.5%且FPG≥126mg/dl）的II型糖尿病患者、40例空腹血糖受损（IFG）（FPG≥110mg/dl且<126mg/dl）的受试者以及190名健康志愿者（FPG<110mg/dl）的血清镁水平。健康志愿者需血压正常且实验室检查正常。纳入组中的受试者按年龄和体重指数（BMI）进行匹配。血糖控制良好和未控制的糖尿病患者的糖尿病病程平均分别为11.4±6.6年和10.9±6.2年，P值无统计学意义。30例（60.0%）血糖控制良好的糖尿病受试者、58例（52.7%）血糖未控制的糖尿病患者、21例（52.5%）IFG受试者以及39例（20.5%）健康志愿者的血清镁水平≤1.7mg/l。无论血糖值如何，血清高密度脂蛋白胆固醇值均随血清镁水平呈显著的分级增加。本研究结果表明，似乎存在一条与血糖无关的致病途径导致的低镁血症参与了高密度脂蛋白胆固醇的降低。
