Cox D P, Muller S, Carlson G W, Murray D
Emory University School of Medicine, Department of Pathology, Atlanta, GA 30322, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Dec;90(6):716-22. doi: 10.1067/moe.2000.109076.
Ameloblastoma is a rare, locally destructive, benign neoplasm of the jawbones, which arises from epithelium derived from the epithelial components of the developing tooth. Ameloblastic carcinoma is the term used to designate any ameloblastoma in which there is histologic evidence of malignancy in the primary tumor, regardless of whether it has metastasized. Most ameloblastic carcinomas are presumed to have arisen de novo, with few cases of malignant transformation of ameloblastoma being apparent. Hypercalcemia is the most common metabolic complication of malignancy. Although malignancy-associated hypercalcemia is often reported in association with other malignancies, it is exceedingly unusual in association with ameloblastoma, malignant ameloblastoma, or ameloblastic carcinoma. We describe a patient with multiple recurrences of ameloblastoma, with subsequent malignant transformation presenting with malignancy-associated hypercalcemia.
成釉细胞瘤是一种罕见的、具有局部破坏性的颌骨良性肿瘤，起源于发育中牙齿上皮成分衍生的上皮组织。成釉细胞癌是指任何原发性肿瘤具有组织学恶性证据的成釉细胞瘤，无论其是否已发生转移。大多数成釉细胞癌被认为是原发的，很少有成釉细胞瘤发生恶性转化的病例。高钙血症是恶性肿瘤最常见的代谢并发症。虽然与恶性肿瘤相关的高钙血症常与其他恶性肿瘤相关报道，但与成釉细胞瘤、恶性成釉细胞瘤或成釉细胞癌相关极为罕见。我们描述了一名成釉细胞瘤多次复发的患者，随后发生恶性转化并出现与恶性肿瘤相关的高钙血症。
