Meloen R H, Puijk W C, Slootstra J W
Pepscan Systems BV, Lelystad, The Netherlands.
J Mol Recognit. 2000 Nov-Dec;13(6):352-9. doi: 10.1002/1099-1352(200011/12)13:6<352::AID-JMR509>3.0.CO;2-C.
Theoretically it seems highly unlikely that relatively small peptides could mimic functionally discontinuous epitopes of antigens. Nevertheless various recent reports show this to be the case. Peptide mimics of protein-, polysaccharide- and DNA-epitopes have been shown to be able to replace the native epitope. Moreover, some of them are able to induce, when used in a vaccine, antibodies with the same activity as that of the antibody used as a template. These mimics, called mimotopes, can be used in vaccines and diagnostics and can be developed more or less systematically using solely antibodies and random, semi-random and dedicated peptide arrays or libraries. Furthermore, the mimotope concept which seems to have proven itself for antibody and antigen interaction can be applied equally well to many receptor ligand interactions and thus may form a new generic approach to the development of drugs. Ltd.
理论上，相对较小的肽似乎极不可能模拟抗原的功能不连续表位。然而，最近的各种报告表明情况确实如此。已证明蛋白质、多糖和DNA表位的肽模拟物能够取代天然表位。此外，其中一些模拟物在用作疫苗时能够诱导出与用作模板的抗体具有相同活性的抗体。这些被称为模拟表位的模拟物可用于疫苗和诊断，并且可以仅使用抗体以及随机、半随机和专用肽阵列或文库或多或少地系统开发。此外，似乎已在抗体和抗原相互作用中得到验证的模拟表位概念同样可以应用于许多受体-配体相互作用，因此可能形成一种开发药物的新通用方法。有限公司
