Wang E, Marincola F M
Dept of Transfusion Medicine, Clinical Center, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1502, USA.
Immunol Today. 2000 Dec;21(12):619-23. doi: 10.1016/s0167-5699(00)01724-2.
Ena Wang and Francesco Marincola propose a novel strategy whereby tumor-host interactions are studied within the melanoma microenvironment by serial gene expression analysis. Methodological constraints and ways to circumvent them are discussed. This approach might improve our understanding of the molecular basis of tumor regression in response to immune manipulation.
伊娜·王和弗朗西斯科·马林科拉提出了一种新策略,即通过连续基因表达分析在黑色素瘤微环境中研究肿瘤与宿主的相互作用。文中讨论了方法上的限制以及规避这些限制的方法。这种方法可能会增进我们对肿瘤在免疫调控下发生消退的分子基础的理解。